Results 131 to 140 of about 34,166 (314)
Words on Wilderness, Spring 1995
, 1995 Newsletter from the Wilderness Institute at the University of Montana.https://scholarworks.umt.edu/wordsonwilderness/1037/thumbnail ...
University of Montana--Missoula. Wilderness Studies and Information Center +1 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Episode 29 : Paradigm Shift : an interview with Dave Aldrich and Bob Mutch
, 2011 Interviewee: Dave Aldrich and Bob Mutch | Interviewer: Debbie Lee | Location: Powell, Idaho | Date: July 16, 2011 | In this episode, titled, Paradigm Shift we hear from Dave Aldrich, who was the wilderness ranger in charge of helping to create the new ...
Debbie Lee; Dave Aldrich; Bob Mutch;
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Ecology and SocietyResearch on human-elephant interactions (HEI) seeks to better understand relationships between people and elephants with the goal of reducing unwanted interactions for the long-term survival of elephants in social-ecological systems. Many examinations of
Lauren E Redmore
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Developing a Wilderness Quality Index for Continental Europe
LandThis paper presents an updated wilderness quality map, WQI 2.0, for Europe, which extends the existing map (WQI 1.0) to include non-EU states in Eastern Europe.
Iurii Strus, Stephen Carver
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Wilderness School news. Vol. 3, #1. 2011: Apr. 15.
, 2011 Semiannual; Began in 2008?; At head of title: State of Connecticut.; Issue for Dec.
Wilderness School (Connecticut Dept. of Children and Families)
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source