Results 141 to 150 of about 34,166 (314)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Episode 30 : Wyakin Songs : a historical study of Nez Perce
, 2013 Interviewer: Melda Williams | Interviewee: Nez Perce Singer/Narrator | Thank you for joining us for this special thirtieth episode of the Selway-Bitterroot Wilderness History Project. Any historical study of an area like the Selway-Bitterroot ...
Melda Williams; Nez Perce;
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Episode 11 : The Big Storm : an interview with Mark Bohrmann
, 2011 Interviewee: Mack Bohrmann | Interviewer: Debbie Lee | Location: Missoula, MT | Date: April 20, 2011 | In this episode, titled The Big Storm, we listen to Mack Bohrmann tell the story of a wilderness storm, one of many natural elements that users ...
Debbie Lee; Mack Bohrmann;
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FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Wilderness: Promises, Poetry, and Pragmatism
, 1987 Lecture given by Dr. Jay D. Hair, President of the National Wildlife Federation. Introduction by Dr. Edwin E. Krumpe, Director of the University of Idaho Wilderness Research Center. The lecture opens by touching on three aspects of the wilderness debate:
Jay D. Hair
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Wilderness Institute Newsletter (Words on Wilderness) Statement of Purpose
, 1978 Statement of Purpose for the Wilderness Institute\u27s newsletter, Words on Wilderness.https://scholarworks.umt.edu/wordsonwilderness/1010/thumbnail ...
University of Montana (Missoula, Mont. : 1965-1994). Wilderness Studies and Information Center +1 more
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source