Results 41 to 50 of about 262,063 (287)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Spatial Identification and Conservation Gaps of Wilderness Areas in the State-Owned Forest Region of Daxing’anling

Diversity
Wilderness areas are important in maintaining biodiversity, and “retaining existing intact and wilderness areas” is listed as the first of 21 action targets for 2030 in the first draft of the post-2020 Global Biodiversity Framework. However, the quantity
Qingyi Wang, Aihua Fu, Cuicui Yan, Peng Hou, Xiaofeng Luan   +4 more
doaj   +1 more source

“I know it when I see it”: Identifying ocean wilderness using a photo-based survey approach

Global Ecology and Conservation, 2014
“Wilderness” is identified and defined, in large part, as places perceived by people as possessing characteristic qualities and attributes such as remoteness, providing opportunities for solitude, and where the influence of man is not readily apparent ...
Bradley W. Barr, Andrew D. Kliskey
doaj   +1 more source

Classification and Protection Status of Remnant Natural Plant Communities in Arkansas [PDF]

, 1981
A classification and inventory of Arkansas\u27s remaining tracts of relatively undisturbed vegetation was initiated in 1979. Based on extensive literature surveys and field work, the classification includes five physiognomic classes, 17 cover classes ...
Pell, William F.
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Framing the relationship between people and nature in the context of European conservation [PDF]

, 2015
A key controversy in conservation is the framing of the relationship between people and nature. The extent to which the realms of nature and human culture are viewed as separate (dualistic view) or integrated is often discussed in the social sciences. To
Agnoletti, Apollonio, Bauer, Bekoff, Bendrey, Birks, Blanco, Boitani, Castree, Chapron, Cronon, Descola, Descola, Descola, Donlan, Ellen, García, Ghosal, Gunther, Halada, Haraway, Hobbs, Hodder, Ingold, Isselstein, Jones, Kerley, Kirby, Knight, Latour, Latour, Linnartz, Linnell, Liu, Lorimer, López-Bao, Mace, Maffi, Marris, Martin, Marvier, Mattisson, Milton, Monbiot, Mysterud, Navarro, Ordiz, Phalan, Queiroz, Redpath, Robbins, Rubenstein, Schwartz, Selva, Terborgh, Treves, Tsiafouli, Vera, Vos, Watson   +59 more
core   +3 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Streams in the Wilderness [PDF]

, 2014
Miranda Beale analyzes two award-winning novels by Marilynne Robinson, Gilead (2004) and Home (2008), identifying their major themes as the necessity of balancing parental responsibility and God\u27s loving guidance and redemptive power in raising ...
Beale, Miranda
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Ours to Displace, Ours to Protect : The Borderlands of American Indian Histories, Whiteness, and the Wilderness Ideal [PDF]

, 2015
\u27 Ours to Displace, Ours to Protect : The Borderlands of American Indian Histories, Whiteness, and the Wilderness Ideal\u27 is featured in the journal Tapestries: Interwoven voices of local and global identities, volume ...
Lewis, Victoria A
core   +1 more source