Results 81 to 90 of about 262,063 (287)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Forage Yields in Turkey Hill Wilderness in East Texas for White-tailed Deer [PDF]

, 2016
Wilderness areas are often considered quality areas where natural processes occur without human activity. It is often assumed that these unmanaged areas will provide and support quality wildlife habitat. The objective of this study was to evaluate the
Farrish, Kenneth W, Gentzler, Bret, Oswald, Brian P.   +2 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Wilderness Beauty: A Means to Resolve Volitional Doubt [PDF]

, 2010
Doubt is often part of Christian spiritual life. Matured doubt will influence the will (the volition) so as to keep the Christian doubter from acting like a Christian or even desiring the Christian life.
Scalise, Brian T
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

An Annotated Check List of the Birds of the Golden Gate Highlands National Park

Koedoe: African Protected Area Conservation and Science, 1988
This paper presents a check list of 159 bird species occuring in the Golden Gate Higlands National Park and lists another 14 species needing confirmation Temporal distribution of the species on a monthly basis was obtained during one year, between April ...
R.A. Earle, A.B. Lawson
doaj   +1 more source

AN AGENDA FOR THE STUDY OF LAND USE, WILDERNESS DESIGNATION, AND RESOURCE REGULATION IN THE AMERICAN WEST [PDF]

Atemporal and intertemporal use of public lands, the determination of optimal levels of wilderness designation and habitat preservation, and the appropriate regulation of natural resources have all been "hot button" issues in the American West for quite ...
Batabyal, Amitrajeet A.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Rescate y medicina en lugares agrestes: el ejemplo estadounidense

Revista Médica Clínica Las Condes, 2011
Los rescates en lugares remotos y la medicina agreste son áreas que se encuentran en desarrollo desde fines de la década de los sesenta en Estados Unidos.
M.D. Gregory Stiller, C. Nicolás Macchiavello, Dr., M. Felipe Undurraga, Dr.   +2 more
doaj   +1 more source