Results 71 to 80 of about 2,262,131 (334)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Management of multiple traumas in emergency medicine department: A review

Journal of Family Medicine and Primary Care, 2019
One of the main causes of adults' disability during their working age is multiple trauma. The process of medical care of patients who are injured seriously is still a challenging job.
Parvin Kashani, Amin Saberinia
doaj   +1 more source

More than sense of place? Exploring the emotional dimension of rural tourism experiences [PDF]

, 2014
It is widely suggested that participation in rural tourism is underpinned by a sense of rural place or “rurality”. However, although nature and the countryside have long been recognised as a source of spiritual or emotional fulfilment, few have explored ...
Aitchison C., Baerenholdt J., Barsham D., Bremer T., Bunce M., Burchardt J., Cain T., Casey E., Cloke P., Coble T., Cresswell T., Darby W., de Vries H., de Vulpian A., Deborah Jepson, Denyer S., Digance J., Driver B., Drury P., Flanagan K., Fredrickson L., Harrison C., Heelas P., Heintzman P., Kastenholz E., Klenke K., Little D., Mannell R., Mason M., Montes S., Nash D., Newby H., O’Neill C., Patton M., Relph E., Richard Sharpley, Seaton T., Sharpley R., Short J., Swatton A., Teasedale W., Theos, Timothy D., Timothy D., Tuan Y., Tuan Y., Urry J., Walton J., Weinberg D., Woods M.   +49 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Social Medicine Grand Rounds: A Collaborative Education Hub to Promote Action on Social Determinants of Health Across Community Sectors in Rural Alaska

Social Medicine, 2018
Background: The connection between social stratification and health inequalities in the United States suggests the need for medical education and practice to address social determinants of health as a key condition for achieving health equity.
Lucas Jacob Trout, Kristine Salters, Robert Inglis, Matthew Tobey, Jennifer Kasper, N. Stuart Harris   +5 more
doaj  

Effects of Audible Human Disturbances on Koala (Phascolarctos Cinereus) Behavior in Queensland, Australia and Implications for Management [PDF]

, 2015
Koala populations are declining, and a contributing factor is stress, which can lead to greater susceptibility to disease. Koalas need about twenty hours of rest daily to remain healthy and unstressed.
Kinsella, Galina
core   +1 more source

Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness. [PDF]

, 2013
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility.
Begley, J, Boos, C, Hooper, T, King, R, Mellor, A, O'Hara, J, Piper, R, Smith, C, Stacey, M, Turner, S, Woods, DR, Yarker, J   +11 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Personality Profiles of Iditasport Ultra-marathon Participants

, 2003
Each February, competitors convene in Big Lake, Alaska, to participate in the “Iditasport Human Powered Ultra-Marathon”. Who would attempt this challenging race? Personality might be one factor predicting participation.
Case, H. Samuel, Evans, Deborah S., Hughes, Sherri Lind, Stuempfle, Kristin J.   +3 more
core   +1 more source

Cherokee relationships to land: Reflections on a historic plant gathering agreement between Buffalo National River and the Cherokee Nation [PDF]

, 2020
This piece reflects on my involvement in a historic agreement between Buffalo National River and the Cherokee Nation regarding the implementation of the “Gathering of Certain Plants or Plant Parts by Federally Recognized Indian Tribes for Traditional ...
Carroll, Clint
core