Results 31 to 40 of about 9,381 (248)

Integrating Patient‐Reported Quality Measures in SLE: Development of the American College of Rheumatology Implementation Guide

Arthritis Care &Research, Accepted Article.
Objective To support high‐quality, patient‐centered care for systemic lupus erythematosus (SLE), the American College of Rheumatology (ACR) developed evidence‐based measures incorporating clinical and patient‐reported outcomes measures (PROMs). Using the Consolidated Framework for Implementation Research (CFIR), we conducted semi‐structured interviews ...
Catherine Nasrallah, Cherish Wilson, Christine Hariz, Christie M Bartels, Shanthini Kasturi, Wambui Machua, Amy Bennett, Kate Chiseri, Allison Plitman, Starla Hairston Blanks, April Jorge, Patti Katz, Jinoos Yazdany, Shivani Garg   +13 more
wiley   +1 more source

Crack Repair in Hydroxyapatite Bioceramics Using an Ultraviolet Ultrafast Laser

Advanced Materials Interfaces, EarlyView.
The study proposes an ultrafast ultraviolet laser approach to repair hidden tooth cracks, which has been preliminarily validated on HAP. Moreover, this technique aims to strengthen the native enamel structure rather than introducing a foreign filling material.
Yan Xue, Kai Zheng, Yang Liao, Jing Cao, Xupeng Yuan, Fusong Yuan, Yuxin Leng   +6 more
wiley   +1 more source

Wilson's disease - clinical picture, factors influencing disease progression, treatment methods

Quality in Sport
Wilson's disease, also known as hepatolenticular degeneration, is a rare genetic metabolic disorder that leads to excessive accumulation of copper in the body, particularly in the liver and brain.
Monika Korga, Paweł Pawlik, Przemysław Zaroda, Jakub Wawrzkowicz, Patrycja Niewinna, Paweł Dąda, Dominika Mańdziuk , Michał Żuchowski, Klaudia Kołodziej , Wojciech Kołodziej    +9 more
doaj   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology

Angewandte Chemie, EarlyView.
We develop Cu+‐ and Cu2+‐specific DNAzyme fluorescent probes to visualize both copper redox states in living neurons. Aβ oligomers cause intracellular copper overload, triggering FDX1 dependent cuproptosis and generating ROS. This work links copper redox imbalance with Aβ pathology and offers a selective, sensitive way to monitor copper homeostasis in ...
Xiangli Shao, Zhenglin Yang, Zhihao Xu, Weijie Guo, Whitney Lewis, Boyi Gan, Yi Lu   +6 more
wiley   +2 more sources

ПСЕВДОВИЛЬСОН-КОНОВАЛОВ — ВОЗВРАЩЕНИЕ К ПРИМАТУ КЛИНИЧЕСКОГО ДИАГНОЗА В ХХI ВЕКЕ

Архивъ внутренней медицины, 2015
Tremor disease Wilson’s is demands obligatory differential diagnosis with multiple sclerosis. The article presents a clinical case of mistaken diagnosis, “Wilson’s disease” rather than the diagnosis “multiple sclerosis” in young men.
З. А. Гончарова, С. С. Лунева, С. И. Сенин   +2 more
doaj   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Wilson disease

Medical Electron Microscopy, 2002
Wilson disease is an autosomal recessive inherited disorder of copper metabolism, characterized by the accumulation of copper in the body due to defective biliary copper excretion from hepatocytes. Recently, novel components involved in copper metabolism, including Menkes disease protein (ATP7A), Wilson disease protein (ATP7B), and copper chaperones ...
C A, Davie, A H V, Schapira
openaire   +5 more sources

Wilson’s disease in a child: a difficult path to diagnosis (clinical case)

Zdorovʹe Rebenka
The article presents data on the etiology, pathogenesis and clinical manifestations of Wilson’s disease, and also describes a diagnostically complex clinical case and own observation of a patient with Wilson’s disease. Wilson’s disease is a chronic liver
O.M. Вabadzhanian, O.V. Shutova, N.V. Pavlenko, I.G. Solodovnychenko, K.V. Voloshyn   +4 more
doaj   +1 more source