Results 41 to 50 of about 463,017 (306)

Experimental Study of Mitigation of Wind-Induced Vibration in Asymmetric Cable-Stayed Bridge Using Sharp Wind Fairings

Applied Sciences, 2021
This paper investigated the aerodynamic response features of an asymmetric cable-stayed bridge. The wind resistance design parameters for judging the response were first determined, afterwards the bridge dynamic characteristics were analyzed for ...
Guohui Zhao, Zhichao Wang, Shuo Zhu, Jianming Hao, Jun Wang   +4 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Analysis of wind-induced vibration effect parameters in flexible cable-supported photovoltaic systems: A case study on ground anchor with steel cables

Case Studies in Construction Materials
The pre-stressed flexible cable-supported photovoltaic (PV) systems (FCSPSs) are gradually becoming the preferred PV structure for large-span and mountain photovoltaic power plants.
Yan Fei Zhu, Ying Huang, Chuanzhao Xu, Bin Xiao, Chang Hong Chen, Yao Yao   +5 more
doaj   +1 more source

Sectional Model Wind Tunnel Test and Research on the Wind-Induced Vibration Response of a Curved Beam Unilateral Stayed Bridge

Buildings, 2022
The linear curve distribution of the beam and the asymmetrical layout of the stay cables may have beneficial or adverse influences on cable-stayed bridges.
Shuang Zhao, Jiahao Chen, Jiahao Yue, Zhitao Yan, Jun Liu, Bin Zhang, Jianfeng Chen   +6 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Calculation of the Dynamic Wind-Induced Deflection Response of Overhead Lines: Establishment and Analysis of the Multi-Rigid-Body Model

IEEE Access, 2020
Wind-induced deflection flashover severely endangers the normal operation of overhead transmission lines. This paper proposes a multi-rigid-body model for the accurate and efficient calculation of the dynamic wind-induced deflection response of overhead ...
Xin Hu, Zhangqi Wang, Rui Tian
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A novel partitioned numerical coupling between vortex particle method–structure–smoothed particle hydrodynamics models for wind-induced vibration analysis

Results in Engineering
The article introduces a novel weakly-partitioned numerical coupling method implemented to analyze the wind-induced response of low-damped structures incorporating a Tuned Liquid Damper (TLD).
Victor Vîlceanu, Samir Chawdhury, Guido Morgenthal   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modelling the aerodynamics of vertical-axis wind turbines in unsteady wind conditions

, 2013
Most numerical and experimental studies of the performance of vertical-axis wind turbines have been conducted with the rotors in steady, and thus somewhat artificial, wind conditions - with the result that turbine aerodynamics, under varying wind ...
Scheurich, Frank, Brown, Richard
core   +1 more source