Results 41 to 50 of about 9,070,941 (298)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

A novel bridge wind-induced vibration response prediction algorithm based on temporal convolution network.

PLoS ONE
The stiffness of the high pier, large span rigid bridge in the operation period increases its ability to resist wind-induced vibration. However, the structural properties of high piers and long cantilevers make it susceptible to wind-induced vibration ...
Youlai Qu, Xiangrong Bai, Tianhao Zhu, Shixu Zuo   +3 more
doaj   +1 more source

Assessing the Aeroacoustic Response of a Vehicle to Transient Flow Conditions from the Perspective of a Vehicle Occupant [PDF]

, 2014
On-road, a vehicle experiences unsteady flow conditions due to turbulence in the natural wind, moving through the unsteady wakes of other road vehicles and travelling through the stationary wakes generated by roadside obstacles. Separated flow structures
Sims-Williams, D.B., Oettle, Nicholas, Dominy, R.G., Oettle, N.R., Dominy, Robert, Sims-Williams, David   +5 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Turbulence-Induced Buffeting Response and Vibration Mitigation of a Cable-Supported Photovoltaic System

Eng
The stochastic buffeting response characteristics and control performance of a cable-supported flexible photovoltaic system under turbulent inflow were investigated through aeroelastic wind tunnel tests in an atmospheric boundary layer corresponding to ...
Zhening Shi, Genshen Fang, Dongfang Huo, Shengyuan Liu, Hechuan Jiang, Wei Huangfu, Zuopeng Wen, Yaojun Ge   +7 more
doaj   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Analysis of wind-induced vibration effect parameters in flexible cable-supported photovoltaic systems: A case study on ground anchor with steel cables

Case Studies in Construction Materials
The pre-stressed flexible cable-supported photovoltaic (PV) systems (FCSPSs) are gradually becoming the preferred PV structure for large-span and mountain photovoltaic power plants.
Yan Fei Zhu, Ying Huang, Chuanzhao Xu, Bin Xiao, Chang Hong Chen, Yao Yao   +5 more
doaj   +1 more source

A Review on Aerodynamic Characteristics and Wind-Induced Response of Flexible Support Photovoltaic System

Atmosphere, 2023
Photovoltaic (PV) system is an essential part in renewable energy development, which exhibits huge market demand. In comparison with traditional rigid-supported photovoltaic (PV) system, the flexible photovoltaic (PV) system structure is much more ...
Fubin Chen, Yuzhe Zhu, Weijia Wang, Zhenru Shu, Yi Li   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source