Results 41 to 50 of about 33,070 (259)

A novel partitioned numerical coupling between vortex particle method–structure–smoothed particle hydrodynamics models for wind-induced vibration analysis

Results in Engineering
The article introduces a novel weakly-partitioned numerical coupling method implemented to analyze the wind-induced response of low-damped structures incorporating a Tuned Liquid Damper (TLD).
Victor Vîlceanu, Samir Chawdhury, Guido Morgenthal   +2 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effect of Wind Environment on the response of Buildings in Oman

Sultan Qaboos University Journal for Science, 1998
An investigation has been carried out to study the effect of the wind parameters on the response of multistory buildings subjected to wind induced forces.
Mohammed Qamaruddin, Salem K. Al-Oraimi
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sensitivity Analysis of the Effectiveness of Tuned Mass Dampers to Reduce the Wind-Induced Torsional Responses

Latin American Journal of Solids and Structures
Use of Tuned Mass Dampers (TMDs) to reduce the wind-induced torsional response of structures has been investigated in the literature by assuming that the wind excitations can be approximated by harmonic forces or white noise random processes; however ...
A. Pozos-Estrada, H.P. Hong
doaj   +1 more source

Evaluation of Wind-Induced Response Bounds of High-Rise Buildings Based on a Nonrandom Interval Analysis Method

Shock and Vibration, 2018
The traditional wind-induced response analysis of high-rise buildings conventionally considers the wind load as a stationary stochastic process. That is, for a certain wind direction angle, the reference wind speed (usually refers to the mean wind speed ...
Xianglei Wei, An Xu, Ruohong Zhao
doaj   +1 more source

Wind-Induced Response Analysis for a Fatigue-Prone Asymmetric Steel Arch Bridge with Inclined Arch Ribs

Advances in Materials Science and Engineering, 2022
Steel arch bridges with inclined arch ribs under strong wind fields are prone to fatigue damage due to the stress concentration at the position of hanger connections.
You-Hua Su, Yan-Ru Wu, Qing Sun
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source