Results 61 to 70 of about 463,017 (306)

Information paper: evidence on wind farms and human health [PDF]

open access: yes, 2015
This Information Paper provides Australians with a summary of the evidence on possible health effects of wind farms in humans and explains how NHMRC developed its summary based on the findings of independent reviews of the evidence.
National Health and Medical Research Council
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Study on Wind-Induced Dynamic Response and Statistical Parameters of Skeleton Supported Saddle Membrane Structure in Arching and Vertical Direction

open access: yesBuildings
Wind tunnel tests and numerical simulations are the mainstream methods to study the wind-induced vibration of structures. However, few articles use statistical parameters to point out the differences and errors of these two research methods in exploring ...
Ziye Chen   +6 more
doaj   +1 more source

Evaluation of Wind-Induced Response Bounds of High-Rise Buildings Based on a Nonrandom Interval Analysis Method

open access: yesShock and Vibration, 2018
The traditional wind-induced response analysis of high-rise buildings conventionally considers the wind load as a stationary stochastic process. That is, for a certain wind direction angle, the reference wind speed (usually refers to the mean wind speed ...
Xianglei Wei, An Xu, Ruohong Zhao
doaj   +1 more source

The interaction between flow-induced vibration mechanisms of a square cylinder with varying angles of attack [PDF]

open access: yes, 2012
This study examines the influence of angle of attack of a square section cylinder on the cylinder’s flow-induced vibration, where the direction of the vibration is transverse to the oncoming flow.
Nemes, Andras   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Motion-induced wind forces of a slender prism

open access: yes, 2017
The motion-induced wind forces of a slender prism were investigated using a forced vibration technique. The prism was driven to oscillate by an actuator in cross-wind direction and the unsteady distributed pressures, under different wind velocities and ...
Chen, Zhengshun   +2 more
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

The occupant response to wind-induced tall building motion in New Zealand

open access: yes, 2013
1014 central business district workers in Wellington New Zealand were surveyed about wind-induced building motion. 41.7% reported wind-induced building motion.
Walton, Darren   +2 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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