Results 51 to 60 of about 359,992 (302)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Experimental Study of Mitigation of Wind-Induced Vibration in Asymmetric Cable-Stayed Bridge Using Sharp Wind Fairings

Applied Sciences, 2021
This paper investigated the aerodynamic response features of an asymmetric cable-stayed bridge. The wind resistance design parameters for judging the response were first determined, afterwards the bridge dynamic characteristics were analyzed for ...
Guohui Zhao, Zhichao Wang, Shuo Zhu, Jianming Hao, Jun Wang   +4 more
doaj   +1 more source

How wind and sun shape trees into fractals? [PDF]

, 2018
Trees are self-similar branching structures, hierarchically organized with longer and thicker branches near the roots. With a mechanically-based numerical model, we show how self-similarity can emerge through natural selection.
Christophe, Eloy
core  

Modeling circulation patterns induced by spatial cross-shore wind variability in a small-size coastal embayment [PDF]

, 2016
This contribution shows the importance of the cross-shore spatial wind variability in the water circulation in a small-sized micro-tidal bay. The hydrodynamic wind response at Alfacs Bay (Ebro River delta, NW Mediterranean Sea) is investigated with a ...
Cerralbo Peñarroya, Pablo, Espino Infantes, Manuel, Grifoll Colls, Manel   +2 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Sectional Model Wind Tunnel Test and Research on the Wind-Induced Vibration Response of a Curved Beam Unilateral Stayed Bridge

Buildings, 2022
The linear curve distribution of the beam and the asymmetrical layout of the stay cables may have beneficial or adverse influences on cable-stayed bridges.
Shuang Zhao, Jiahao Chen, Jiahao Yue, Zhitao Yan, Jun Liu, Bin Zhang, Jianfeng Chen   +6 more
doaj   +1 more source

Occurrence rate of extreme magnetic storms

, 2012
Statistical analysis of occurrence rate of magnetic storms induced by different types of interplanetary drivers is made on the basis of OMNI data for period 1976-2000.
Lodkina, I. G., Nikolaeva, N. S., Yermolaev, M. Yu., Yermolaev, Yu. I.   +3 more
core   +1 more source

Interannual variability of the tropical Atlantic independent of and associated with ENSO: Part I. The North Tropical Atlantic [PDF]

, 2006
The interannual variability of the tropical Atlantic ocean-atmosphere system is examined using 50 years of sea-surface temperature (SST) and re-analysis data, and satellite data when available.
Bishop, Bretherton, Carton, Carton, Chang, Chang, Chang, Curtis, Czaja, Darnell, Delecluse, Dommenget, Elliott, Enfield, Fairall, Ferranti, Giannini, Gupta, Handoh, Handoh, Hirst, Hoskins, Hoskins, Houghton, Huang, Huang, Joyce, Jung, Kistler, Klein, Lau, Liebmann, Liu, Mariotti, Marshall, Matthews, Mehta, Mo, Mo, Nobre, Okumura, Peng, Peng, Pozo-Vazquez, Ruiz-Barradas, Ruiz-Barradas, Saravanan, Spencer, Sutton, Sutton, Tourre, Tseng, Wu, Xie, Xie, Xie, Zebiak   +56 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source