Results 91 to 100 of about 284,191 (261)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Delayed X-Ray Brightening Accompanied by Variable Ionized Absorption Following a Tidal Disruption Event

The Astrophysical Journal
Supermassive black holes can experience super-Eddington peak mass fallback rates following the tidal disruption of a star. The theoretical expectation is that part of the infalling material is expelled by means of an accretion disk wind, whose ...
T. Wevers, M. Guolo, D. R. Pasham, E. R. Coughlin, F. Tombesi, Y. Yao, S. Gezari   +6 more
doaj   +1 more source

Moving heavy quarkonium entropy, effective string tension, and the QCD phase diagram

, 2018
The entropy and effective string tension of the moving heavy quark-antiquark pair in the strongly coupled plasmas are calculated by using a deformed an anti-de Sitter/Reissner-Nordstr$\ddot{o}$m black hole metric.
Chen, Xun, Feng, Sheng-Qin, Shi, Ya-Fei, Zhong, Yang   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

GS&E journal > Large Deflection Glass Facade in Typhoon Area: Taikoo Place 2 Podium Wall

Challenging Glass Conference Proceedings, 2020
The case study presented is a 195 meters tall office tower with a raised podium made of full height glass panels, up to 15 meters high. The panels are only restrained by prestressed high-strength stainless-steel rods, lying entirely in the glass panel ...
Giovanni De Mari
doaj  

Research on Longitudinal Vibration Characteristic of the Six-Cable-Driven Parallel Manipulator in FAST

Advances in Mechanical Engineering, 2013
The first adjustable feed support system in FAST is a six-cable-driven parallel manipulator. Due to flexibility of the cables, the cable-driven parallel manipulator bears a concern of possible vibration caused by wind disturbance or internal force from ...
Zhihua Liu, Xiaoqiang Tang, Zhufeng Shao, Liping Wang, Lewei Tang   +4 more
doaj   +1 more source

Maxometers (peak wind speed anemometers) [PDF]

, 1973
An instrument for measuring peak wind speeds under severe environmental conditions is described, comprising an elongated cylinder housed in an outer casing.
Camp, D. W., Kaufman, J. W., Turner, R. E.   +2 more
core   +1 more source

Luminosity of a quark star undergoing torsional oscillations and the problem of gamma ray bursts

, 2009
We discuss whether the winding-up of the magnetic field by differential rotation in a new-born quark star can produce a sufficiently-high, energy, emission rate of sufficiently long duration to explain long gamma-ray bursts.
Aksenov, Alcock, Alcock, Aly, Aly, Aly, Aly, Asseo, Bardou, Bastrukov, Bejger, Berezhiani, Berezhiani, Biskamp, Bombaci, Bonazzola, Bucciantini, Burrows, Cheng, Cheng, Cheng, Contopoulos, Dai, Dai, Dar, Dar, De Rújula, Dessart, Drago, Drago, Drago, Drago, Fryer, Gaensler, Goldreich, Haberl, Haensel, Haensel, Heiselberg, Heyvaerts, Heyvaerts, Iwamoto, J. Heyvaerts, Kluzniak, Low, Lugones, Lynden-Bell, M. Bejger, Madsen, Madsen, Michel, Mikic, Mészáros, Obergaulinger, Obergaulinger, Ouyed, Ouyed, P. Haensel, Paczynski, Paczynski, Rajagopal, Rincon, Ruderman, S. Bonazzola, Salvati, Shternin, Spruit, Steiner, Thompson, Usov, Usov, Wang, Wolfson, Zhang, Zhang, Zhang, Ziolkowski   +76 more
core   +2 more sources