Results 91 to 100 of about 9,061,461 (261)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Wind power in the UK : a guide to the key issues surrounding onshore wind power development in the UK [PDF]

, 2012
This report is summarised in the Welsh language in 'Ynni gwynt : ateb eich cwestiynau'.This report is summarised in 'Wind power : your questions answered'.This report aims to help policy-makers and planners balance genuine local concerns with wider ...
Sustainable Development Commission
core   +2 more sources

GS&E journal > Large Deflection Glass Facade in Typhoon Area: Taikoo Place 2 Podium Wall

Challenging Glass Conference Proceedings, 2020
The case study presented is a 195 meters tall office tower with a raised podium made of full height glass panels, up to 15 meters high. The panels are only restrained by prestressed high-strength stainless-steel rods, lying entirely in the glass panel ...
Giovanni De Mari
doaj  

Research on Longitudinal Vibration Characteristic of the Six-Cable-Driven Parallel Manipulator in FAST

Advances in Mechanical Engineering, 2013
The first adjustable feed support system in FAST is a six-cable-driven parallel manipulator. Due to flexibility of the cables, the cable-driven parallel manipulator bears a concern of possible vibration caused by wind disturbance or internal force from ...
Zhihua Liu, Xiaoqiang Tang, Zhufeng Shao, Liping Wang, Lewei Tang   +4 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Analysis of the Impact of Wind Speeds on Pantograph-Catenary Interactions in Electrified Highway Systems

Kongzhi Yu Xinxi Jishu
Electrified highways supply electric energy in real time to heavy trucks through overhead contact systems installed on both sides of the roadway. Interactions between these overhead contact systems and vehicle-mounted bipolar pantographs are identified ...
ZHU Zongkun, CHEN Jinyu, WANG Henglong, WANG Kuang   +3 more
doaj  

Assessment of Hydrodynamic Performance and Motion Suppression of Tension Leg Floating Platform Based on Tuned Liquid Multi-Column Damper

Journal of Marine Science and Engineering
To address the unstable motion of a tension leg platform (TLP) for floating wind turbines in various sea conditions, an improved method of incorporating a tuned liquid multi-column damper (TLMCD) into the TLP foundation is proposed.
Fuyin Cui, Shuling Chen, Hongbin Hao, Changzhi Han, Ruidong Ni, Yueyue Zhuo   +5 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source