Results 51 to 60 of about 9,061,461 (261)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Investigation of wind turbine flow and wake [PDF]
, 2014 This paper is dedicated to the investigation and analysis of wind turbine wake. An experimental work is undertaken in wind tunnel on a horizontal axis wind turbine model.
MASSOUH, Fawaz, DOBREV, Ivan
core
Wind Energy Information Guide 2004 [PDF]
, 2004 The guide provides a list of contact information and Web site addresses for resources that provide a range of general and technical information about wind energy, including general information, wind and renewable energy, university programs and research ...
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Ingeniare: Revista Chilena de Ingeniería, 2009 A controlled wind generation system for a stand alone application is presented in this paper. A cascaded step-up/step-down power electronic converters topology is proposed to control the wind power system in the whole wind speed range.
Miguel López, Jean-Claude Vannier
doaj
EnergiesThe strong nonlinearity of shallow-water waves significantly affects the dynamic response of floating offshore wind turbines (FOWTs), introducing additional complexity in motion behavior.
Hanbo Zhai +6 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Wind Energy Teacher's Guide [PDF]
, 2003 This guide, created by the American Wind Association, with support from the U.S. Department of Energy, is a learning tool about wind energy targeted toward grades K-12.
core +1 more source
Float-stacked graphene–PMMA laminate
Nature CommunicationsSemi-infinite single-atom-thick graphene is an ideal reinforcing material that can simultaneously improve the mechanical, electrical, and thermal properties of matrix.
Seung-Il Kim +10 more
doaj +1 more source