Results 61 to 70 of about 284,191 (261)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
EnergiesThe strong nonlinearity of shallow-water waves significantly affects the dynamic response of floating offshore wind turbines (FOWTs), introducing additional complexity in motion behavior.
Hanbo Zhai +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Float-stacked graphene–PMMA laminate
Nature CommunicationsSemi-infinite single-atom-thick graphene is an ideal reinforcing material that can simultaneously improve the mechanical, electrical, and thermal properties of matrix.
Seung-Il Kim +10 more
doaj +1 more source
From Generation to Reuse: A Circular Economy Strategy Applied to Wind Turbine Production
DesignsThe environmental impact of wind turbine rotor blades, both during manufacturing and at the end of their life cycle, can be significant. The aim of this study was to define and test a methodology for recycling the waste resulting from their production ...
Ana Rita Caramelo +2 more
doaj +1 more source
Suppression of transverse vibration of elevator rope using vertical vibration of counterweight
Nihon Kikai Gakkai ronbunshu, 2015 An elevator rope for high-rise building is forcibly excited by the displacement of the building caused by earthquakes and wind forces. In high-rise building, the elevator rope may resonate with the natural frequency of the building; hence, effective ...
Ibuki HIROSE, Hiroyuki KIMURA, Kou OGAWA
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Ingeniare: Revista Chilena de Ingeniería, 2009 A controlled wind generation system for a stand alone application is presented in this paper. A cascaded step-up/step-down power electronic converters topology is proposed to control the wind power system in the whole wind speed range.
Miguel López, Jean-Claude Vannier
doaj
High-Mast Light Poles Anchor Nut Loosening In Alaska - An Investigation Using Field Monitoring and Finite-Element Analysis [PDF]
, 2014 INE/AUTC 14 ...
Hamel, Scott, Hoisington, David
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