Results 151 to 160 of about 3,702,210 (399)

Massachusetts Offshore Wind Future Cost Study [PDF]

open access: yes, 2016
The Special Initiative on Offshore Wind is an independent project at the University of Delaware's College of Earth, Ocean and Environment that supports the advancement of offshore wind as part of a comprehensive solution to the most pressing energy ...
Deniz Ozkan   +2 more
core  

ULF waves excited by negative/positive solar wind dynamic pressure impulses at geosynchronous orbit [PDF]

open access: bronze, 2010
X. Y. Zhang   +9 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Président Vent du Soir d'Elfriede Jelinek ou le kitsch historique: Les totalitarismes valsent au Bal de l'Opéra [PDF]

open access: yes, 2009
National audienceRéactualisation de la féérie satirique Vent du Soir ou l'horrible festin de Johann Nestroy, mise en musique par Jacques Offenbach, le dramuscule Président Vent du Soir met en scène un président cannibale, sur fond d'île exotique, dont ...
Wind, Priscilla
core   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

EU-Norsewind : Investigation of flow distortion effects on offshore instrumentation [PDF]

open access: yes, 2009
In 2008 the EC programme NORSEWInD kicked off with a mission to deliver high quality offshore wind speed data for the wind industry. The aim of the project is to deliver offshore wind speed data to the wind industry by measuring offshore wind speed data ...
Fabre, S.   +4 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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