Results 131 to 140 of about 1,752,983 (309)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Western Wind Quintet, October 10, 1980
, 2019 Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, MIchigan on Oct. 10, 1980, 8:00 p.m., program no.
Western Wind Quintet
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 2013 Presented in this paper are the results of numerical simulation of bushfire enhanced wind and its impact on buildings of various shapes. Using an extended computation domain, the velocity and pressure fields around three buildings which are exposed to ...
Kwok, Kenny C. S. (R14040) +4 more
core
A two-component transport model for solar wind fluctuations: Waves plus quasi-2D turbulence
, 2010 We present a model for the transport of solar wind fluctuations, based on the assumption that they can be well-represented using two distinct components: a quasi-2D turbulence piece and a wave-like piece.
Matthaeus, William H. +3 more
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
, 2012 This report is summarised in the Welsh language in 'Ynni gwynt : ateb eich cwestiynau'.This report is summarised in 'Wind power : your questions answered'.This report aims to help policy-makers and planners balance genuine local concerns with wider ...
Sustainable Development Commission
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Analysis of Extreme Wind Pressure Based on Extreme Value Distribution Theory
AtmosphereWhen extreme wind pressure is predicted based on the extreme value distribution theory, the sampling time–distance and sample volume of wind pressure data are important influencing factors. To discuss and analyze the influence of time–distance and sample
Weihu Chen, Yuji Tian, Fan Bai
doaj +1 more source