Results 151 to 160 of about 1,752,983 (309)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Western Wind Quintet, February 18, 1982
, 2019 Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan on February 18, 1982, 8:00 p.m., program no.
Western Wind Quintet
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Definition of a 5-MW Reference Wind Turbine for Offshore System Development
, 2009 J. Jonkman +3 more
semanticscholar +1 more source
Blade-Element/Momentum Technique for Rotors operating in Wind Tunnels
, 2003 In the past 25 years various investigations of wind turbine aerodynamics have been performed in wind tunnels (see e.g. Ronsten et al. [1], Vermeer [2], Schreck et al. [al]). Compared to full-scale field measurements, experiments performed in wind tunnels
Sørensen, Dan Nørtoft +1 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Effects of wind-induced tall building vibrations on human motor performance
, 2013 Prolonged exposure to wind-induced vibrations in tall buildings can cause discomfort, impair task performance, and even trigger motion sickness symptoms.
Hau, Chui Luen Vera +3 more
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Transmission connected wind curtailment with increasing wind capacity connection
, 2009 Paper presented at IEEE Power & Energy Society General Meeting, July 26-30, 2009, Calgary, CanadaMany countries have ambitious plans to increase wind energy penetration levels in the near future. With a low capacity factor and even lower capacity credit,
Burke, Daniel J. +5 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source