Results 41 to 50 of about 92,207 (251)
Wind Farm Wakes from SAR and Doppler Radar
Remote Sensing, 2020 We retrieve atmospheric wake characteristics at the wind farm Westermost Rough from Sentinel-1 Synthetic Aperture Radar (SAR) images. For the first time, co-located reference measurements of the full flow field around the wind farm are available from ...
Tobias Ahsbahs +3 more
doaj +1 more source
Comparison of OpenFOAM and EllipSys3D for neutral atmospheric flow over complex terrain [PDF]
Wind Energy Science, 2016 The flow solvers OpenFOAM and EllipSys3D are compared in the case of neutral atmospheric flow over terrain using the test cases of Askervein and Bolund hills.
D. Cavar +7 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Power curve and wake analyses of the Vestas multi-rotor demonstrator [PDF]
Wind Energy Science, 2019 Numerical simulations of the Vestas multi-rotor demonstrator (4R-V29) are compared with field measurements of power performance and remote sensing measurements of the wake deficit from a short-range WindScanner lidar system.
M. P. van der Laan +11 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A method to assess the accuracy of sonic anemometer measurements [PDF]
Atmospheric Measurement Techniques, 2019 We propose a method to assess the accuracy of atmospheric turbulence measurements performed by sonic anemometers and test it by analysis of measurements from two commonly used sonic anemometers, a Metek USA-1 and a Campbell CSAT3, at two locations in ...
A. Peña, E. Dellwik, J. Mann
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source