Results 51 to 60 of about 96,971 (258)

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Power curve and wake analyses of the Vestas multi-rotor demonstrator [PDF]

Wind Energy Science, 2019
Numerical simulations of the Vestas multi-rotor demonstrator (4R-V29) are compared with field measurements of power performance and remote sensing measurements of the wake deficit from a short-range WindScanner lidar system.
M. P. van der Laan, S. J. Andersen, N. Ramos García, N. Angelou, G. R. Pirrung, S. Ott, M. Sjöholm, K. H. Sørensen, J. X. Vianna Neto, M. Kelly, T. K. Mikkelsen, G. C. Larsen   +11 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

The Global Atlas for Siting Parameters project: Extreme wind, turbulence, and turbine classes

Wind Energy, 2022
Summary The Global Atlas for Siting Parameters project compiles a suite of models into a complex modeling system, uses up‐to‐date global datasets, and creates global atlases of siting parameters at a spatial resolution of 275 m.
Xiaoli Guo Larsén, Neil Davis, Ásta Hannesdóttir, Mark Kelly, Lasse Svenningsen, René Slot, Marc Imberger, Bjarke Tobias Olsen, Rogier Floors   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Comparison of Large Eddy Simulations of a convective boundary layer with wind LIDAR measurements [PDF]

Advances in Science and Research, 2012
Vertical profiles of the horizontal wind speed and of the standard deviation of vertical wind speed from Large Eddy Simulations of a convective atmospheric boundary layer are compared to wind LIDAR measurements up to 1400 m. Fair agreement regarding both
J. G. Pedersen, M. Kelly, S.-E. Gryning, R. Floors, E. Batchvarova, A. Peña   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A method to assess the accuracy of sonic anemometer measurements [PDF]

Atmospheric Measurement Techniques, 2019
We propose a method to assess the accuracy of atmospheric turbulence measurements performed by sonic anemometers and test it by analysis of measurements from two commonly used sonic anemometers, a Metek USA-1 and a Campbell CSAT3, at two locations in ...
A. Peña, E. Dellwik, J. Mann
doaj   +1 more source

Knowledge Engineering for Wind Energy

Wind Energy Science
Abstract. With the rapid evolution of the wind energy sector, there is an ever-increasing need to create value from the vast amounts of data made available both from within the domain, as well as from other sectors. This article addresses the challenges faced by wind energy domain experts in converting data into domain knowledge, connecting and ...
Y. Marykovskiy, Y. Marykovskiy, T. Clark, J. Day, M. Wiens, C. Henderson, J. Quick, I. Abdallah, A. M. Sempreviva, J.-P. Calbimonte, E. Chatzi, S. Barber   +11 more
openaire   +6 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source