Results 71 to 80 of about 1,193,137 (291)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Turbulence characterization from a forward-looking nacelle lidar [PDF]
Wind Energy Science, 2017 We present two methods to characterize turbulence in the turbine inflow using radial velocity measurements from nacelle-mounted lidars. The first uses a model of the three-dimensional spectral velocity tensor combined with a model of the spatial ...
A. Peña, J. Mann, N. Dimitrov
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Comparison between upwind and downwind designs of a 10 MW wind turbine rotor [PDF]
Wind Energy Science, 2019 The size of wind turbines has been steadily growing in the pursuit of a lower cost of energy by an increased wind capture. Within this trend, the vast majority of wind turbine rotors have been designed based on the conventional three-bladed upwind ...
P. Bortolotti, A. Kapila, C. L. Bottasso
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Optimization of Synthetic Inertial Response from Wind Power Plants
Energies, 2018 In this paper the emphasis is on the optimization of synthetic inertial response of wind power plants (WPPs) for power systems with high wind power penetration levels, considering different wind speed operating conditions. The synthetic inertial response
Müfit Altin +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Predicting wind energy generation with recurrent neural networks [PDF]
, 2018 Decarbonizing the energy supply requires extensive use of renewable generation. Their intermittent nature requires to obtain accurate forecasts of future generation, at short, mid and long term.
Béjar Alonso, Javier +2 more
core +1 more source