Results 81 to 90 of about 1,193,137 (291)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Spectral signature of a free pulsar wind in the gamma-ray binaries LS 5039 and LSI +61$\degr$303 [PDF]

open access: yes, 2008
LS 5039 and LSI +61$\degr$303 are two binaries that have been detected in the TeV energy domain. These binaries are composed of a massive star and a compact object, possibly a young pulsar.
Aharonian   +35 more
core   +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Wind Energy in Colombia: A Framework for Market Entry [PDF]

open access: yes
The purpose of this report is to provide decision makers in Colombia (and by extension other countries or regions), who are considering the deployment or consolidation of wind power, with a set of options to promote its use. The options presented are the
Alejandro Deeb   +4 more
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

In-plane compressive responses and failure behaviors of composite sandwich plates with resin reinforced foam core

open access: yesHeliyon
The paper presented an experimental study on the effect of the resin reinforced core configuration and core thickness on in-plane compressive responses and failure behaviors of composite sandwich specimens.
Zhiwen Qin   +6 more
doaj   +1 more source

Wind Energy Technology

open access: yes, 2009
Electricity is regarded as one of the indispensable means to growth of any country’s economy. This source of power is the heartbeat of everything from the huge metropolitans, industries, worldwide computer networks and our global communication systems down to our homes.
Brandão, Roque Filipe Mesquita   +2 more
openaire   +2 more sources

The Role of Community Values in Wind Energy Development: Exploring the Benefits and Applications of Community Wind for Reducing Local Opposition to Wind Energy Systems [PDF]

open access: yes, 2008
Worldwide, wind energy generation is growing rapidly as a cleaner and less invasive alternative to traditional fossil-fuel energy sources. Yet, in the United States, the advancement of wind energy has been stunted by three factors: (1) the uncertainty of
Vaccaro, Amanda
core   +1 more source

Evaluating the economic return to public wind energy research and development in the United States [PDF]

open access: yes, 2020
The U.S. government has invested in wind energy research since 1976. Building on a literature that has sought to develop and apply methods for retrospective benefit-to-cost evaluation for federal research programs, this study provides a quantitative ...
Millstein, D, Wiser, R
core   +1 more source

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