Results 131 to 140 of about 107,579 (316)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
IEEE AccessThe increasing integration of renewable energy sources (RESs) into the power system reduces system inertia, which presents substantial challenges for maintaining frequency stability.
Duc-Tung Trinh +2 more
doaj +1 more source
Active Management of Distributed Generation based on Component Thermal Properties [PDF]
, 2010 Power flows within distribution networks are expected to become increasingly congested with the proliferation of distributed generation (DG) from renewable energy resources.
JUPE, SAMUEL,CHARLES,EDWARD +1 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Active generation of large scale turbulence in a boundary layer wind tunnel [PDF]
, 2003 The effect of turbulence on bluff body aerodynamics and response in wind flow has been increasingly studied for a wide range of turbulence integral scale.
Cheung, John C. K. +2 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Determining the Impact of Wind on System Costs via the Temporal Patterns of Load and Wind Generation [PDF]
Wind Energy, System Costs, Alternative Energy, Electricity Generation, Environmental Economics and Policy, Resource /Energy Economics and Policy, Q4, Q42, Q54,
Davis, Clay D. +2 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
RENEWABLE ENERGY AS AN ALTERNATIVE OF THE DECENTRALIZATION ENERGY SUPPLY IN UKRAINE
International Journal of Innovative Technologies in Economy, 2018 The scientific article considers the state of the energy sector of the Ukrainian economy and determines a high level of depreciation of equipment, as a result of which conclusions were drawn on the need for the speedy introduction of renewable energy ...
Skrypnyk Andrey +2 more
doaj