Results 141 to 150 of about 107,579 (316)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
IEEE AccessThis research aims to devise a methodology for optimizing the size of a Battery Energy Storage System (BESS) supporting Wind Energy Systems (WES) to enhance power commitment flexibility in the energy market. The methodology involves three essential steps:
Shubham Kashyap, Tirthadip Ghose
doaj +1 more source
The effect of wind-induced building motion in a longitudinal sample of office workers in Wellington, New Zealand [PDF]
, 2015 47 office workers located on high floors and 53 office workers on or near the ground floor in Wellington, New Zealand, completed 1,909 short online surveys across a period of 8 months.
Lamb, Steven (R18264) +2 more
core
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
AlgorithmsGiven the critical importance of accurate energy demand and production forecasting in managing power grids and integrating renewable energy sources, this study explores the application of advanced machine learning techniques to forecast electricity load ...
Zhen Wang +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Wind Collector for the Wind Power Generator
IEEJ Transactions on Power and Energy, 2004 Kamiya, Takashi +5 more
openaire +1 more source
A review of the current status of Small Wind Western Australia and effectiveness of relevant State and Federal policy [PDF]
, 2009 This paper reviews results from recent surveys on small wind electricity generating systems facilitated by the Western Australian Local Government Association (WALGA) together with outcomes from a WALGA/Murdoch University Small Scale Wind Workshop and ...
Pascale, A., Doepel, D., Whale, J.
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source