Results 81 to 90 of about 1,957,794 (246)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Study on wind load characteristics of stadium under tornado. [PDF]

Sci Rep, 2023
Yuan Z, Zhang Z, Tang H.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Research on the impact of irregular structure group construction on rail transit bridge piers and its response to wind load. [PDF]

Sci Rep, 2023
Wang Y, Chen Z, Qi Y.
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

e-wind: An Integrated Engineering Solution Package for Wind Sensitive Buildings and Structures

, 2011
This article introduces "e-wind" program that is currently under development at Wind Engineering Research Center at Tamkang University. e-wind is an effort to integrate the available wind engineering tools, such as wind code, aerodynamic database and ...
Cheng, Chii-ming; Wang, Jenmu; Chang, Cheng-hsin
core  

Wind–Temperature Load Combination Coefficients for Long-Span Hybrid Cable-Stayed Suspension Bridge with Considerations of Load Correlation and Geometry Nonlinearity

Applied Sciences
This study focuses on quantifying wind–temperature load combination coefficients for long-span hybrid cable-stayed suspension bridges (HCSSBs) to overcome limitations of traditional methods in ignoring load correlation and geometry nonlinearity.
Yuzhe Wu, Xiaoyi Zhou, Yuchen Miao, Wen Xiong   +3 more
doaj   +1 more source

The impact of far-reaching offshore cluster wakes on wind turbine fatigue loads [PDF]

Wind Energy Science
With the number of commissioned and planned wind farms increasing rapidly, analysing wind farm cluster wakes becomes essential for resource assessment and lifetime considerations.
A. Anantharaman, A. Anantharaman, J. Schneemann, J. Schneemann, F. Theuer, F. Theuer, L. Beaudet, V. Bernard, P. Deglaire, M. Kühn, M. Kühn   +10 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Base-load cycling on a system with significant wind penetration [PDF]

Certain developments in the electricity sector may result in suboptimal operation of base-load generating units in countries worldwide. Despite the fact they were not designed to operate in a flexible manner, increasing penetration of variable power ...
Troy, Niamh, Denny, Eleanor, O'Malley, Mark   +2 more
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