Results 61 to 70 of about 1,957,794 (246)

Performance and Effect of Load Mitigation of a Trailing-Edge Flap in a Large-Scale Offshore Wind Turbine

Journal of Marine Science and Engineering, 2020
As a result of the large-scale trend of offshore wind turbines, wind shear and turbulent wind conditions cause significant fluctuations of the wind turbine’s torque and thrust, which significantly affect the service life of the wind turbine gearbox
Xin Cai, Yazhou Wang, Bofeng Xu, Junheng Feng   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The analysis of dynamic characteristics and wind-induced displacement response of space Beam String Structure

E3S Web of Conferences, 2018
The Beam String Structure structural system, also called BSS, has the advantages of lighter dead weight and greater flexibility. The wind load is the main design control factor.
Chen Yong Jian, Feng Zhen Fa, Qi Ai, Huang Ying   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel approach to structural load control using intelligent actuators [PDF]

, 2009
The recent trend towards large multi-MW wind turbines resulted in the role of the control system becoming increasingly important. The extension of the role of the controller to alleviate structural loads has motivated the exploration of novel control ...
Leithead, W.E., Neilson, Victoria, Dominguez, S., Dutka, Arkadiusz   +3 more
core   +4 more sources

Numerical wind load estimation of offshore floating structures through sustainable maritime atmospheric boundary layer

International Journal of Naval Architecture and Ocean Engineering, 2020
Wind load is one of the major design loads for the hull and mooring of offshore floating structures, especially due to much larger windage area above water than under water.
Seong Mo Yeon, Joo-Sung Kim, Hyun Joe Kim   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Examination of simplified load model on fatigue analysis of small wind turbine blade using aeroelastic analysis

Nihon Kikai Gakkai ronbunshu, 2015
In this research, probabilistic fatigue load estimation by the aeroelastic modeling was carried out for a small wind turbine with 1m diameter. The results were compared with the simplified load model which is a deterministic method, and quantitative ...
Mitsumasa IINO, Hideki TOKUYAMA, Hiroshi SEGAWA, Makoto IIDA   +3 more
doaj   +1 more source