Results 71 to 80 of about 1,957,794 (246)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Optimal Management of a Wind/CAES Power Plant by means of Neural Network Wind Speed Forecast
, 2007 Some of the major limitations of renewable energy sources are represented by their low power density and intermittent nature, largely depending upon local site and unpredictable weather conditions. These problems concur to increase the unit costs of wind
Vincenzo Marano +7 more
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Aerodynamic Design of Wind Turbine Blades Utilising Nonconventional Control Systems [PDF]
As a result of the significant growth of wind turbines in size, blade load control has become the main challenge for large wind turbines. Many advanced techniques have been investigated aiming at developing control devices to ease blade loading ...
Wiratama, I. Kade
core
NEW APPROACHES FOR VERY SHORT-TERM STEADY-STATE ANALYSIS OF AN ELECTRICAL DISTRIBUTION SYSTEM WITH WIND FARMS [PDF]
, 2010 Distribution networks are undergoing radical changes due to the high level of penetration of dispersed generation. Dispersed generation systems require particular attention due to their incorporation of uncertain energy sources, such as wind farms, and ...
Carpinelli, G. +18 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Application of wind generation capacity credits in the Great Britain and Irish systems [PDF]
, 2010 Paper presented at Cigre 2010, 22nd to 27th August 2010, Paris, FranceThe concept of capacity credit is widely used to quantify the contribution of renewable technologies to securing demand.
Hasche, Bernhard +11 more
core +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Generation of synthetic benchmark electrical load profiles using publicly available load and weather data [PDF]
, 2014 Electrical load profiles of a particular region are usually required in order to study the performance of renewable energy technologies and the impact of different operational strategies on the power grid. Load profiles are generally constructed based on
Pillai, Gobind +3 more
core +1 more source