Results 51 to 60 of about 288,653 (304)
Analytical Simulation of 3D Wind-Induced Vibrations of Rectangular Tall Buildings in Time Domain
Shock and Vibration, 2022 The Monte Carlo simulation method for along-wind loads on tall buildings performed in the time and space domain may be the only analytical viable option for specific problems such as nonlinearity behavior, nonclassically damping, and detailed structural ...
Iván F Huergo +2 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
METHOD OF PROCESSING THE WIND TURBINE TIME HISTORY LOADS BASED ON 6 DEGREES OF FREEDOM
Jixie qiangdu, 2021 A method of simply wind turbine time history loads have been studied in the article,it can be converted the time history loads into some number of load duration distribution. It is based on the standard of ISO6336 by considering 6 degrees of freedom. The
LI JinKu, LIU Wei
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
A novel approach to structural load control using intelligent actuators [PDF]
, 2009 The recent trend towards large multi-MW wind turbines resulted in the role of the control system becoming increasingly important. The extension of the role of the controller to alleviate structural loads has motivated the exploration of novel control ...
Dominguez, S. +4 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Mass-loading of pulsar winds [PDF]
Monthly Notices of the Royal Astronomical Society, 2003 24 pages, 4 ...
openaire +2 more sources
Predicting wind turbine blade loads using vorticity transport and RANS methodologies [PDF]
, 2009 Two computational methods, one based on the solution of the vorticity transport equation, and a second based on the solution of the Reynolds-Averaged Navier-Stokes equations, have been used to simulate the aerodynamic performance of a horizontal axis ...
Brown, Richard +3 more
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source