Results 111 to 120 of about 3,189,300 (321)

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

open access: yesFEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang   +11 more
wiley   +1 more source

Wind Speed Prediction Using a Univariate ARIMA Model and a Multivariate NARX Model

open access: yes, 2016
Two on step ahead wind speed forecasting models were compared. A univariate model was developed using a linear autoregressive integrated moving average (ARIMA). This method’s performance is well studied for a large number of prediction problems.
E. Cadenas   +3 more
semanticscholar   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

open access: yesFEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo   +2 more
wiley   +1 more source

Uncertainty in recent near-surface wind speed trends: a global reanalysis intercomparison

open access: yes, 2017
Reanalysis products have become a tool for wind energy users requiring information about the wind speed long-term variability. These users are sensitive to many aspects of the observational references they employ to estimate the wind resource, such as ...
V. Torralba   +2 more
semanticscholar   +1 more source

Identification of inhibitors of the Salmonella FraB deglycase, a drug target

open access: yesFEBS Open Bio, EarlyView.
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law   +6 more
wiley   +1 more source

One-day ahead wind speed/power prediction based on polynomial autoregressive model

open access: yes, 2017
Wind has been one of the popular renewable energy generation methods in the last decades. Foreknowledge of power to be generated from wind is crucial especially for planning and storing the power.
Oktay Karakus   +2 more
semanticscholar   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

open access: yesFEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang   +7 more
wiley   +1 more source

Wind Mapping of Malaysia Using Ward’s Clustering Method

open access: yesEnergies
Malaysian wind maps used in wind analysis and engineering design are dated back to the last 50 years of wind data. Cotemporally, the mean wind speed was used as the basic wind design and due to changes in the weather condition worldwide, wind monitoring ...
Amar Azhar, Huzaifa Hashim
doaj   +1 more source

Spectral Analysis of Detailed Vertical Wind Speed Profiles [PDF]

open access: bronze, 1969
R. M. Endlich   +2 more
openalex   +1 more source

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