Results 111 to 120 of about 3,612,533 (358)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Unsteady simulation of flow in micro vertical axis wind turbine [PDF]
, 2010 Though wind turbines and windmills have been used for centuries, the application of aerodynamics technology to improve reliability and reduce costs of wind-generated energy has only been pursued in earnest for the past 40 years.
BOIS, Gérard +1 more
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Integrated Optimal Design of a Passive Wind Turbine System: An Experimental Validation [PDF]
, 2010 This work presents design and experimentation of a full passive wind turbine system without active electronic part(power and control). The efficiency of such device can be obtained only if the system design parameters are mutually adapted through an ...
Sareni, Bruno +4 more
core +1 more source
Sub-hourly forecasting of wind speed and wind energy
, 2020 The need to have access to accurate short term forecasts is essential in order to anticipate the energy production from intermittent renewable sources, notably wind energy.
Aurore Dupré +5 more
semanticscholar +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Bidirectional wakes over complex terrain using SCADA data and wake models [PDF]
Wind Energy ScienceWe investigate bidirectional wake effects between two wind turbines of the same type in a hill region in northern Japan using supervisory control and data acquisition (SCADA) data and validate the simulated wakes using 12 wake models. The extent to which
N. Sasanuma +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source