Results 81 to 90 of about 935,111 (345)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Design of mine opposed wind speed and direction sensor

Gong-kuang zidonghua
In response to the current problems of high startup wind speed, complex design schemes, and inability to accurately measure the average wind speed of the entire section of the roadway using wind speed sensors, based on the principle of ultrasonic opposed
AN Sai, ZHAO Zhonghui, ZHANG Lang, LI Wei, PENG Ran   +4 more
doaj   +1 more source

A Composite Uncertainty Forecasting Model for Unstable Time Series: Application of Wind Speed and Streamflow Forecasting [PDF]

, 2020
Na Sun, Shuai Zhang, Peng Tian, Jianzhong Zhou, Xinguo Sun   +4 more
openalex   +1 more source

Maxometers (peak wind speed anemometers) [PDF]

, 1973
An instrument for measuring peak wind speeds under severe environmental conditions is described, comprising an elongated cylinder housed in an outer casing.
Camp, D. W., Kaufman, J. W., Turner, R. E.   +2 more
core   +1 more source

Distributions and Correlation Properties of Offshore Wind Speeds and Wind Speed Increments

Boundary-Layer Meteorology
AbstractWe determine distributions and correlation properties of offshore wind speeds and wind speed increments by analyzing wind data sampled with a resolution of one second for 20 months at different heights above sea level in the North Sea. Distributions of horizontal wind speeds can be fitted to Weibull distributions with shape and scale parameters
Sim, So-Kumneth, Maass, Philipp, Roman, H. Eduardo   +2 more
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Short-term Wind Speed Prediction Based on Wavelet Packet Decomposition and BP Neural Network

Kongzhi Yu Xinxi Jishu, 2019
In this paper, a short-term wind speed prediction method based on BP neural network and wavelet packet decomposition was proposed to solve the problem of insufficient accuracy of wind speed prediction introduced by unstable wind speed signals.
WANG Ning, LUO Rubin, LIAO Jun, LI Jun, JIANG Yi, YANG Zechuan, YUAN Junjie   +6 more
doaj  

A novel wind speed prediction approach based on wind speed fluctuation characteristic extraction and dual decomposition

AIP Advances
The accuracy of wind speed forecasting plays a crucial role in the operation of the power grid. However, the intermittency and randomness of wind present significant challenges to the accuracy of wind speed predictions.
Xiong Xiong, Mingqi Zhao, Xin Chen, Ruilin Zou, Yifan Xu, Xiaoling Ye   +5 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Iron charge states observed in the solar wind [PDF]

, 1983
Solar wind measurements from the ULECA sensor of the Max-Planck-Institut/University of Maryland experiment on ISEE-3 are reported. The low energy section of approx the ULECA sensor selects particles by their energy per charge (over the range 3.6 keV/Q to
Galvin, A. B., Gloeckler, G., Hovestadt, D., Ipavich, F. M., Klecker, B., Scholer, M.   +5 more
core   +1 more source