Results 81 to 90 of about 2,255,502 (294)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Design of mine opposed wind speed and direction sensor

Gong-kuang zidonghua
In response to the current problems of high startup wind speed, complex design schemes, and inability to accurately measure the average wind speed of the entire section of the roadway using wind speed sensors, based on the principle of ultrasonic opposed
AN Sai, ZHAO Zhonghui, ZHANG Lang, LI Wei, PENG Ran   +4 more
doaj   +1 more source

An estimate of the Geosat altimeter wind speed algorithm at high wind speeds [PDF]

Journal of Geophysical Research: Oceans, 1993
Existing wind speed algorithms for satellite altimeters have been developed from data in the range 0 to 20 m/s. At higher wind speeds the available algorithms diverge alarmingly. By comparing Geosat altimeter values of the radar cross section with model predictions of the surface winds during satellite overpasses of tropical cyclones, a wind speed ...
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The evaluation of the critical wind speed that overturns a vehicle with space-averaged instantaneous wind velocity

Nihon Kikai Gakkai ronbunshu, 2018
Under the existing method based on a detailed equation for evaluating the wind speed that can cause a vehicle to overturn, it is assumed that the crosswind blows the vehicle at the same wind speed uniformly over the entire length of the vehicle body ...
Tomohiro TATEMATSU, Koji NAKADE, Katsuhiro KIKUCHI   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Possible biases in wind speed measurements from merchant ships [PDF]

, 2004
Wind speed measurements obtained from ship-mounted anemometers are biased by the presence of the ship which distorts the airflow to the anemometer. Until recently this bias had only been quantified for a few well-exposed anemometer sites on individual ...
Yelland, M.J., Moat, B.I., Molland, A.F.
core   +1 more source

Analysis of wind parameters for Wuhan Qingshan Yangtze River Highway Bridge

暴雨灾害, 2019
The wind climate characteristics around the Wuhan Qingshan Yangtze River Highway Bridge are analyzed based on the wind data of the newly built wind tower at the Bridge site, Huangpi and the Provincial Agricultural Exhibition Center automatic weather ...
Changqiong HU, Xueting ZHANG, Biqiang WANG, Yi FANG, Qi TONG, Lili DING   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Short-term Wind Speed Prediction Based on Wavelet Packet Decomposition and BP Neural Network

Kongzhi Yu Xinxi Jishu, 2019
In this paper, a short-term wind speed prediction method based on BP neural network and wavelet packet decomposition was proposed to solve the problem of insufficient accuracy of wind speed prediction introduced by unstable wind speed signals.
WANG Ning, LUO Rubin, LIAO Jun, LI Jun, JIANG Yi, YANG Zechuan, YUAN Junjie   +6 more
doaj