Results 51 to 60 of about 20,816 (262)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Wind Speed Predictability Accuracy with Height Using LiDAR Based Measurements and Artificial Neural Networks

Applied Artificial Intelligence, 2021
Accurate prediction of future wind speed is important for wind energy integration into the power grid. Wind speeds are usually measured and predicted at lower heights, while modern wind turbines have hub heights of about 80–120 m.
M. Mohandes, S. Rehman, H. Nuha, M.S. Islam, F.H. Schulze   +4 more
doaj   +1 more source

A Singular Spectrum Analysis and Gaussian Process Regression-Based Prediction Method for Wind Power Frequency Regulation Potential

Energies, 2022
The development of primary frequency regulation (FR) technology has prompted wind power to provide support for active power control systems, and it is critical to accurately assess and predict the wind power FR potential.
Xianbo Du, Jilai Yu
doaj   +1 more source

Predicting The Wind Speeds Of Solar-Like Stars

, 2016
Some aspects of stellar magnetic activity such as X-ray emission are relatively easy to observe, while others, such as the geometry of the magnetic field are rather more difficult. Indeed, typically only the large-scale (or low-order) components of the field can be mapped.
Jardine, Moira, See, V., Vidotto, A.
openaire   +3 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Spatial Prediction of Wind Speed Data

Korean Journal of Applied Statistics, 2010
In this paper, we introduce the linear regression model taking the parametric spatial association structure into account and employ it to five-year averaged wind speed data measured at 460 meteorological monitoring stations in South Korea. From the prediction map obtained by the model with spatial association parameters, we can see that inland area has
Seung-Hwan Jeong, Man-Sik Park, Kee-Whan Kim   +2 more
openaire   +2 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Applicability Evaluation of Wind Turbine Wake Models

南方能源建设
[Introduction] The wake effect of wind turbines is an important cause of energy loss in wind farms. The wake study of wind turbines is beneficial to optimization of the turbine arrangement and improvement of the economic efficiency of wind farms. [Method]
Sheng LI, Wenpeng GE, Jiacheng WU, Chunming QU, Rui SUN   +4 more
doaj   +1 more source

Improving multi-modal wind speed prediction of short and medium term with a bi-clustered machine learning method [PDF]

Atmospheric Measurement Techniques
Accurate prediction of wind speed is of great importance for stable and reliable operation of wind farms. However, the single numerical model forecast cannot provide precise wind speed outputs due to the defect of its physical parameterization scheme ...
Y. Zhang, L. Li, X. Xiong, X. Yin, X. Zhang, F. Cui, R. Dang, W. Liu, L. Zhai, P. Wang, P. Sun, W. Lu, W. Zhang   +12 more
doaj   +1 more source