Results 101 to 110 of about 3,638,388 (305)

Turbulence Length Scales in a Boundary Layer Wind Tunnel

, 2001
Turbulence length scales are important parameters affecting the aerodynamic characteristics and response of structures in wind flow. It is therefore essential to simulate the wind velocity profile models in scaling these turbulence length scale ...
Cheung, John C. K., Melbourne, William H.   +1 more
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The effect of ship shape and anemometer location on wind speed measurements obtained from ships

, 2005
Wind speed measurements obtained from ship-mounted anemometers are biased by the distortion of the airflow around the ship's hull and superstructure. These wind speed measurements are used both in numerical weather prediction and in climate studies and ...
Yelland, M.J., Moat, B.I., Molland, A.F.
core   +1 more source

Dynamic response of temporary structures due to wind loading

, 2015
Due to the lack of an international standard for the design of temporary stage structures, there have been several instances where temporary stage structures have failed and resulted in injury or death during strong wind events (Tomasetti, 2012).
Bishay, A. (x), Pagano, T., Kwok, Kenny C. S. (R14040), Dang, J. (x)   +3 more
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Wind-stress misalignment in the presence of swells in the Bay of Bengal

Frontiers in Marine Science
This study investigates the directional characteristics of momentum flux, τ, under diverse wind-wave conditions in the Bay of Bengal (BoB). Using high-frequency data from an eddy covariance flux system deployed on a moored buoy, we identify various cases
Abhijith Raj, Abhijith Raj, B. Praveen Kumar, Venkata Jampana, P. G. Remya, Hyodae Seo, N. Sureshkumar, E. Pattabhi Rama Rao   +7 more
doaj   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

The Response of a Stochastically Forced ENSO Model to Observed Off-Equatorial Wind Stress Forcing

, 2009
This study investigates the response of a stochastically forced coupled atmosphere-ocean model of the equatorial Pacific to off-equatorial wind stress anomaly forcing.
McGregor, Shayne, Holbrook, Neil J., Power, Scott B.   +2 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source