Results 81 to 90 of about 3,638,388 (305)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Drag coefficients derived from ocean current and temperature profiles at high wind speeds

open access: yesTellus: Series A, Dynamic Meteorology and Oceanography, 2018
Two bottom-up methods based on the turbulence closure and bulk model were utilised to estimate drag coefficients at high wind speeds based on ocean current and temperature profiles observed by two subsurface buoys during Typhoon Megi in the South China ...
Zhongshui Zou   +4 more
doaj   +1 more source

Postflexion larvae and juvenile daily growth patterns of the Alborán Sea sardine (Sardina pilchardus Walb.): influence of wind

open access: yesScientia Marina, 2006
The Alborán Sea is a hydrographically complex and variable area in which wind-driven coastal upwelling occurs. Its most abundant small pelagic resource is the sardine (Sardina pilchardus), which is subject to major interannual oscillations.
Francisco Alemany   +7 more
doaj   +1 more source

Pedestrian level wind environment around isolated buildings resulted from twisted wind profiles

open access: yes, 2015
The pedestrian-level wind environment influenced by twisted wind profiles were evaluated through a series of wind tunnel tests. In the tests, more than 200 Irwin sensors were installed to measure the wind speeds at pedestrian level around five isolated ...
Tse, Kam-Tim   +3 more
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The impact of waves and sea spray on modelling storm track and development

open access: yesTellus: Series A, Dynamic Meteorology and Oceanography, 2015
In high wind speed conditions, sea spray generated by intensely breaking waves greatly influences the wind stress and heat fluxes. Measurements indicate that the drag coefficient decreases at high wind speeds. The sea spray generation function (SSGF), an
Lichuan Wu   +3 more
doaj   +1 more source

University Wind Ensemble, November 2, 1975

open access: yes, 2016
Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan, November 2, 1975, program no. 41 of the Department of Music’s 1975-1976 season.University Wind Ensemble, Carl Bjerregaard, conductor ; Stephen ...
Western Michigan University. Wind Ensemble
core  

Mean, variability and trend of Southern Ocean wind stress: Role of wind fluctuations [PDF]

open access: yes, 2018
The Southern Ocean (SO) surface westerly wind stress plays a fundamental role in driving the Antarctic Circumpolar Current and the global meridional overturning circulation.
Xiaoming Zhai   +7 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Observational Insights of Nearshore Wind Stress and Parameterizations From Gaussian Process Regressions

open access: yesGeophysical Research Letters
The nearshore wind stress, u∗2, is examined using machine‐learning models for air‐ocean data collected via new flux buoys deployed across four experiments.
C. A. Benbow, J. H. MacMahan
doaj   +1 more source

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