Results 71 to 80 of about 3,638,388 (305)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Motion-induced wind forces of a slender prism
, 2017 The motion-induced wind forces of a slender prism were investigated using a forced vibration technique. The prism was driven to oscillate by an actuator in cross-wind direction and the unsteady distributed pressures, under different wind velocities and ...
Chen, Zhengshun +2 more
core
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Novel methods for fatigue data editing for horizontal axis wind turbine blades [PDF]
Wind turbine blades are the most critical components of wind turbines. Full-scale blade fatigue testing is required to verify that the blades possess the strength and service life specified in the design.
Pratumnopharat, Panu
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
SAMOS Air‐Sea Fluxes: 2005–2024
Geoscience Data JournalAn updated dataset of air/sea turbulent fluxes has been created for 2005–2024 using three bulk flux algorithms and input data from a collection of research vessels contributing to the Shipboard Automated Meteorological and Oceanographic Systems (SAMOS ...
Marc Castells +3 more
doaj +1 more source
Optimal Management of a Wind/CAES Power Plant by means of Neural Network Wind Speed Forecast
, 2007 Some of the major limitations of renewable energy sources are represented by their low power density and intermittent nature, largely depending upon local site and unpredictable weather conditions. These problems concur to increase the unit costs of wind
Vincenzo Marano +7 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source