Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Sea ice led to poleward-shifted winds at the Last Glacial Maximum: the influence of state dependency on CMIP5 and PMIP3 models [PDF]
, 2016 Louise C. Sime +6 more
openalex +1 more source
Establishing baselines for predicting change in ambient sound metrics, marine mammal, and vessel occurrence within a US offshore wind energy area [PDF]
, 2023 Sofie M. Van Parijs +10 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Geophysical Research LettersWe produced global 0.25° three‐dimensional distribution of horizontal wind vectors (or 3D winds) by tracking water vapor from the hyperspectral infrared sounders and microwave sounders aboard two polar satellites (NOAA‐20 and Suomi‐NPP) that have ...
A. Ouyed +5 more
doaj +1 more source
Unprecedented wind erosion and perturbation of surface geochemistry marks the Anthropocene in Australia [PDF]
, 2013 Samuel K. Marx +5 more
openalex +1 more source
Convolutional neural network framework for wind turbine electromechanical fault detection [PDF]
, 2023 Emilie Stone +3 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source