Results 51 to 60 of about 1,025,779 (340)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Bio-Wire

, 2022
Design of a semiconducting Bio-Wire developed from Silane Self-Assembled Monolayers, Neutravidin bio-films, and Carbon nanomaterials. The development of Self-Assembled Monolayers and highly specific Neutravidin bio-films have been characterized. 
Ushnik Ghosh (12298151)
core   +1 more source

The Effect of Fitness on Performance, Exertion, and Cognition During Simulated Firefighter Occupational Tasks

Journal of Functional Morphology and Kinesiology
Background: Fitness is relevant for firefighter occupational performance, but its influence on exertion and cognition during occupational tasks remains unclear.
Philip J. Agostinelli, Nicholas C. Bordonie, Braxton A. Linder, Ann M. Robbins, Parker L. Jones, Lee F. Reagan, C. Brooks Mobley, Matthew W. Miller, William M. Murrah, JoEllen M. Sefton   +9 more
doaj   +1 more source

Wind Farm Area Shape Optimization Using Newly Developed Multi-Objective Evolutionary Algorithms

Energies, 2021
In recent years, wind farm layout optimization (WFLO) has been extendedly developed to address the minimization of turbine wake effects in a wind farm.
Nicolas Kirchner-Bossi, Fernando Porté-Agel   +1 more
doaj   +1 more source

Microstructure and mechanical properties of wire + arc additively manufactured 2024 aluminum alloy components: As-deposited and post heat-treated

Journal of Manufacturing Processes, 2019
Restricted by the type of commercial aluminum wire, 2024 aluminum alloy cannot be built through conventional single wire + arc additive manufacturing technology.
Zewu Qi, B. Qi, Bao-Qiang Cong, Hongye Sun, Gang Zhao, Jia-Luo Ding   +5 more
semanticscholar   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Robust Control for Steer-by-Wire Vehicles [PDF]

, 2005
The design and analysis of steer-by-wire systems at the actuation and operational level is explored. At the actuation level, robust force feedback control using inverse disturbance observer structure and active observer algorithm is applied to enhance ...
Cortesao, Rui, Bajçinca, N., Cortesão, R., Hauschild, M., Hauschild, Markus, Bajcinca, Naim   +5 more
core   +1 more source

Protective Gear Negatively Impacts Police Officer Mobility, Stability, and Power Generation

Journal of Functional Morphology and Kinesiology
Background: Protective gear is a critical part of the police officer uniform. The required protective gear weighs over 9 kg and is rigid and bulky, creating deficits in physical performance essential for completing officer’s daily tasks and increasing ...
Katherine A. Frick, Philip J. Agostinelli, Frances K. Neal, Nicholas C. Bordonie, C. Brooks Mobley, JoEllen M. Sefton   +5 more
doaj   +1 more source

A New Streamwise Scaling for Wind Turbine Wake Modeling in the Atmospheric Boundary Layer

Energies, 2022
In this study, we aim to investigate if there is a scaling of the streamwise distance from a wind turbine that leads to a collapse of the mean wake velocity deficit under different ambient turbulence levels.
Dara Vahidi, Fernando Porté-Agel
doaj   +1 more source

Review of Wire Arc Additive Manufacturing for 3D Metal Printing

International Journal of Automation Technology, 2019
Wire arc additive manufacturing (WAAM) is a crucial technique in the fabrication of 3D metallic structures. It is increasingly being used worldwide to reduce costs and time.
John Li, M. R. Alkahari, N. Rosli, R. Hasan, M. N. Sudin, F. Ramli   +5 more
semanticscholar   +1 more source