Results 91 to 100 of about 584,417 (340)

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

Metabolic profile, bioavailability and toxicokinetics of zearalenone-14-glucoside in rats after oral and intravenous administration by liquid chromatography high-resolution mass spectrometry and tandem mass spectrometry [PDF]

, 2019
Zearalenone-14-glucoside (ZEN-14G), a key modified mycotoxin, has attracted a great deal of attention due to the possible conversion to its free form of zearalenone (ZEN) exerting toxicity.
De Boevre, Marthe, De Saeger, Sarah, Li, Yanshen, Li, Yi, Rao, Zhenghua, Sun, Feifei, Tan, Haiguang, Yang, Shupeng, Zhang, Huiyan, Zhou, Jinhui   +9 more
core   +1 more source

Aortic depressor nerve differences between Wistar and Wistar‐Kyoto rats

The FASEB Journal, 2012
Previous reports from our laboratory [1, 2, 3] showed differences on the morphology of the aortic depressor nerve (ADN) between normotensive Wistar‐Kyoto (WKY) and spontaneously hypertensive rats (SHR). The aim of the present study was to investigate if there are morphological and morphometric differences on the AND of two different normotensive rats ...
Milena Menezes de Amorim, Helio Cesar Salgado, Letícia Oliveira Neri da Silva, Valéria Paula Sassoli Fazan, Vânia Alice de Aguiar Mendes   +4 more
openaire   +2 more sources

Wistar Diabetic Fatty Rat [PDF]

ILAR Journal, 1990
Wistar diabetic fatty (WDF/Ta-/a) rats were developed by Ikeda et al. (1981) to provide a rat model of non-insulindependent diabetes mellitus (NIDDM). Human NIDDM is typically characterized by adult onset and varying degrees of obesity, hyperglycemia, hyperinsulinemia, insulin resistance, glucose intolerance, and peripheral neuropathy.
David B. West, Richard G. Peterson, M. R. C. Greenwood, Ruth Kava   +3 more
openaire   +2 more sources

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

Antidiarrhoeal Activity of Musa paradisiaca Sap in Wistar Rats

Evidence-Based Complementary and Alternative Medicine, 2015
The folkloric claim of Musa paradisiaca sap in the management of diarrhoea is yet to be substantiated or refuted with scientific data. Therefore, the aim of the current study was to screen the sap of M.
M. Yakubu, Quadri Olaide Nurudeen, S. S. Salimon, Monsurat O. Yakubu, R. O. Jimoh, M. O. Nafiu, M. A. Akanji, A. Oladiji, F. Williams   +8 more
semanticscholar   +1 more source

Oral Intake of Sardinella Longiceps Oil the Decrease of Tnf-? and Il-6 Levels in Atherosclerotic Wistar Rat [PDF]

, 2011
Lifestyle changes to consumption of variegated instant food may be associated several heath hazards, such as obesity, dyslipidemia, and atheroschlerosis.
Astawa, I. N. (I), Sudewa, A. A. (A), Wahjuni, S. (S), Wita, I. W. (I)   +3 more
core  

Short-term therapy with rosiglitatzone, a PPAR-¿ agonist improves metabolic profile and vascular function in non-obese lean wistar rats [PDF]

, 2012
A number of preclinical and clinical studies have reported blood-pressure-lowering benefits of thiazolidinediones in diabetic subjects and animal models of diabetes.
Abubakari, Abdul-Razak, Itua, Imose, Naderali, Ebrahim K., Naderali, Mohammad M.   +3 more
core   +1 more source

Ultrastructural investigation of the aortic depressor nerve in Wistar and Wistar‐Kyoto rats

The FASEB Journal, 2012
Ultrastructural study of the aortic depressor nerve (ADN) [1] showed differences on the morphology and morphometry between normotensive Wistar‐Kyoto (WKY) and spontaneously hypertensive rats (SHR), particularly in the number of unmyelinated fibers. The aim of the present study was to investigate if there are ultrastructural differences on the AND of ...
Vânia Alice de Aguiar Mendes, Valéria Paula Sassoli Fazan, Helio Cesar Salgado, Milena Menezes de Amorim, Letícia Oliveira Neri da Silva   +4 more
openaire   +2 more sources

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

Advanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen   +7 more
wiley   +1 more source