Short-term therapy with rosiglitatzone, a PPAR-¿ agonist improves metabolic profile and vascular function in non-obese lean wistar rats [PDF]
, 2012 A number of preclinical and clinical studies have reported blood-pressure-lowering benefits of thiazolidinediones in diabetic subjects and animal models of diabetes.
Abubakari, Abdul-Razak +3 more
core +1 more source
Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury
British Journal of Clinical Pharmacology, EarlyView.Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra +8 more
wiley +1 more source
Nature Communications, 2017 DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases.
Ami Patel +21 more
doaj +1 more source
Targeting CARM1 in ovarian cancer with EZH2 and PARP inhibitors
Molecular & Cellular Oncology, 2020 Coactivator-associated arginine methyltransferase 1 (CARM1)-expressing high-grade serous ovarian cancers are characterized by poor prognosis and limited therapeutic options.
Sergey Karakashev, Rugang Zhang
doaj +1 more source
Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat II: chronic dosing causes developmental delay [PDF]
, 2007 We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat, using chronically exposed rats to ensure continuous exposure of the fetus. 5-6 week old rats were exposed
Bell, David Robert +11 more
core +1 more source
Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors. [PDF]
, 2017 Tumor-associated macrophages (TAM) contribute to all aspects of tumor progression. Use of CSF1R inhibitors to target TAM is therapeutically appealing, but has had very limited anti-tumor effects.
Albert Lo +90 more
core +2 more sources
GLP‐1 agonists and the gut microbiome: A bidirectional relationship
British Journal of Clinical Pharmacology, EarlyView.Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath +2 more
wiley +1 more source
Female and male Wistar rats (Rattus norvegicus) discriminate diets according to energetic quantity [PDF]
, 2020 The food choice of animals is influenced by several factors including the quantity and nutrients available. It is not known, however, whether faced with alternatives that present the same amount of food, with similar flavor and obtained with the same ...
Aragon, Davi Casadele +4 more
core
Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
core +2 more sources
Developmental Dynamics, EarlyView.Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito +9 more
wiley +1 more source