Results 91 to 100 of about 427,006 (340)

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

open access: yesAdvanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong   +9 more
wiley   +1 more source

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

open access: yesNature Communications, 2017
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases.
Ami Patel   +21 more
doaj   +1 more source

Subchronic Toxicity of Green Algae (Spyrogyra SP.) Ethanolic Extract on Hematologic Parameters [PDF]

open access: yes, 2016
Green Algae, an organism with active substance such as phytomelatonin, has potential to be developed as Indonesian traditional medicine. As the long term addition of Green Algae ethanol extract (Ekstrak etanol ganggang hijau, EEGH) influences the ...
Devi, A. (Anggita)   +5 more
core  

Differential Sensitivity to Morphine in Spontaneously Hypertensive and Normotensive Wistar-Kyoto and Wistar Rats

open access: yesClinical and Experimental Hypertension. Part A: Theory and Practice, 1987
In spontaneously hypertensive rats (SHR) a diminished responsiveness for nociceptive stimuli is present, which might be associated with alterations in endogenous opioid peptide and receptor systems. In SHR, normotensive Wistar-Kyoto controls (WKY) and in Wistar rats the effects of acute morphine administration on pain sensitivity and body temperature ...
Frans P. Nijkamp   +2 more
openaire   +3 more sources

Microgel Aspect Ratio Influences Injectable Granular Hydrogel Scaffold Pore Structure and Cellular Invasion for Tissue Repair

open access: yesAdvanced Science, EarlyView.
Granular hydrogels are being developed for the repair of tissues, mostly with the use of spherical microgels. Here, injectable granular hydrogels formed from anisotropic particles (i.e., rod‐like) are explored to improve cellular invasion by increasing scaffold void volume fraction.
Gabriel J. Rodriguez‐Rivera   +11 more
wiley   +1 more source

Discriminating Different Classes of Toxicants by Transcript Profiling [PDF]

open access: yes, 2004
Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing.
Albertini, Silvio   +6 more
core   +2 more sources

Comparative Mechanical Study of Isolated Papillary Muscle from Wistar-Kyoto and Wistar Rats.

open access: yesJapanese Heart Journal, 1994
Isolated papillary muscles have often been used in myocardial mechanical function studies. The objective of the present study was to compare the mechanical function of papillary muscle isolated from left ventricle between Wistar (W) and Wistar-Kyoto (WKY) rats of different ages (1, 3, 6 and 12 months), in order to examine whether there is a difference ...
Okoshi, Marina Politi   +3 more
openaire   +5 more sources

Structure‐Tailoring Cerium Nanozymes with Self‐Cascade ROS Scavenging Catalysis Modulate the Microbiota‐Gut‐Joint Axis for Rheumatoid Arthritis Therapy

open access: yesAdvanced Science, EarlyView.
A valence‐engineered CeOX nanozyme, with its Ce3+/Ce4+ ratio precisely controlled within the range of 0.27 to 0.93 through Au deposition, performs a self‐cascade oxidase‐superoxide dismutase‐peroxidase reaction, enabling continuous reactive oxygen species scavenging while minimizing oxygen generation.
Ge Wang   +10 more
wiley   +1 more source

Padronização de modelo experimental adequado a estudos do efeito do exercício na artrite

open access: yesEinstein (São Paulo)
OBJETIVO: Padronizar um modelo experimental de monoartrite crônica induzida por adjuvante completo de Freund apropriado à análise do efeito da deambulação na nocicepção e no edema articular. MÉTODOS: Foram avaliados os seguintes fatores para a indução da
Raquel Pinheiro Gomes   +5 more
doaj   +1 more source

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

open access: yesNature Communications, 2020
ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren   +11 more
doaj   +1 more source

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