Results 71 to 80 of about 165,402 (265)

Targeting CARM1 in ovarian cancer with EZH2 and PARP inhibitors

Molecular & Cellular Oncology, 2020
Coactivator-associated arginine methyltransferase 1 (CARM1)-expressing high-grade serous ovarian cancers are characterized by poor prognosis and limited therapeutic options.
Sergey Karakashev, Rugang Zhang
doaj   +1 more source

Comparative Mechanical Study of Isolated Papillary Muscle from Wistar-Kyoto and Wistar Rats.

Japanese Heart Journal, 1994
Isolated papillary muscles have often been used in myocardial mechanical function studies. The objective of the present study was to compare the mechanical function of papillary muscle isolated from left ventricle between Wistar (W) and Wistar-Kyoto (WKY) rats of different ages (1, 3, 6 and 12 months), in order to examine whether there is a difference ...
Okoshi, Marina Politi, Padovani, Carlos Roberto, Nardi, S. C., Cicogna, Antonio Carlos   +3 more
openaire   +4 more sources

Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review

ChemFoodChem, EarlyView.
ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida, Éverton A. Pereira, Patricia Severino, Cristina Blanco‐Llamero, Sandra L. Santos, Luciana N. Andrade, Ricardo G. Amaral, Eliana B. Souto   +7 more
wiley   +1 more source

Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats

Journal of Veterinary Medical Science, 2019
Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats.
HAMADA, Mizuki, IHARA, Tsubasa, FURUSE, Mitsuhiro   +2 more
openaire   +3 more sources

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model

Nature Communications, 2017
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases.
Ami Patel, Antonio DiGiandomenico, Ashley E. Keller, Trevor R. F. Smith, Daniel H. Park, Stephanie Ramos, Katherine Schultheis, Sarah T. C. Elliott, Janess Mendoza, Kate E. Broderick, Megan C. Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kar Muthumani, Laurent Humeau, Lily I. Cheng, Leslie Wachter-Rosati, C. Kendall Stover, Niranjan Y. Sardesai, David B. Weiner   +21 more
doaj   +1 more source

Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats

ESC Heart Failure, Volume 12, Issue 2, Page 1304-1315, April 2025.
Parts of the figure were drawn by using pictures from Servier Medical Art. Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction
Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen   +16 more
wiley   +1 more source

Padronização de modelo experimental adequado a estudos do efeito do exercício na artrite

Einstein (São Paulo)
OBJETIVO: Padronizar um modelo experimental de monoartrite crônica induzida por adjuvante completo de Freund apropriado à análise do efeito da deambulação na nocicepção e no edema articular. MÉTODOS: Foram avaliados os seguintes fatores para a indução da
Raquel Pinheiro Gomes, Elisangela Bressan, Tatiane Morgana da Silva, Monique da Silva Gevaerd, Carlos Rogério Tonussi, Susana Cristina Domenech   +5 more
doaj   +1 more source

Aortic depressor nerve differences between Wistar and Wistar‐Kyoto rats

The FASEB Journal, 2012
Previous reports from our laboratory [1, 2, 3] showed differences on the morphology of the aortic depressor nerve (ADN) between normotensive Wistar‐Kyoto (WKY) and spontaneously hypertensive rats (SHR). The aim of the present study was to investigate if there are morphological and morphometric differences on the AND of two different normotensive rats ...
Vânia Alice de Aguiar Mendes, Milena Menezes de Amorim, Letícia Oliveira Neri da Silva, Helio Cesar Salgado, Valéria Paula Sassoli Fazan   +4 more
openaire   +1 more source

Semaglutide normalizes increased cardiomyocyte calcium transients in a rat model of high fat diet‐induced obesity

ESC Heart Failure, Volume 12, Issue 2, Page 1386-1397, April 2025.
Sequeira et al. reveal how the glucagon‐like peptide‐1 receptor agonist (GLP‐1‐RA) semaglutide restores cardiomyocyte function in rats subjected to a high‐fat/high‐fructose diet (HFD). Employing fluorescence‐ and patch‐clamp technology in isolated cardiac myocytes, they demonstrate that semaglutide reverses HFD‐induced activation of L‐type calcium ...
Vasco Sequeira, Julia Theisen, Katharina J. Ermer, Marie Oertel, Anton Xu, David Weissman, Katharina Ecker, Jan Dudek, Martin Fassnacht, Alexander Nickel, Michael Kohlhaas, Christoph Maack, Ulrich Dischinger   +12 more
wiley   +1 more source