Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve +6 more
wiley +1 more source
Tail clamping induces anxiety-like behaviors and visceral hypersensitivity in rat models of non-erosive reflux disease. [PDF]
World J PsychiatryLv M +8 more
europepmc +1 more source
Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley +1 more source
Glutamate transmission in the prelimbic cortex and nucleus accumbens shell is involved in ethanol reinforcement and drinking in rats. [PDF]
Front Behav NeurosciTan X, McBride WJ, Ding ZM.
europepmc +1 more source
Phytotherapy Research, EarlyView.Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli +4 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source
Subacute 28-Day OECD-Guided Oral Toxicity Study of <i>Escherichia coli</i> 5C (LMG S-33222) in Wistar Rats and Immunocompromised Nude Mice. [PDF]
J Microbiol BiotechnolDi Pierro F +8 more
europepmc +1 more source
Rheumatology &Autoimmunity, EarlyView.Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen +6 more
wiley +1 more source
Glucocorticoid Signaling-Associated Gene Expression in the Hippocampus and Frontal Cortex of Chronically Isolated Normotensive and Hypertensive Rats and the Responsiveness to Acute Restraint Stress. [PDF]
Int J Mol SciKvichansky A +8 more
europepmc +1 more source
Monolithic 3D Nanoelectrode Arrays on CMOS Circuitry for Scalable, High‐Resolution Neural Recording
Small, EarlyView.A CMOS‐integrated in vitro electrophysiology platform with 26,400 3D nanoelectrodes enables high‐resolution extracellular recordings with enhanced spatial sensitivity. Wafer‐scale, low‐temperature post‐fabrication monolithic integration of nanoelectrodes on foundry‐made CMOS chips preserves circuit functionality and electrical performance.
Aziliz Lecomte +4 more
wiley +1 more source