Results 171 to 180 of about 433,567 (330)

Stromal cell‐derived factor‐1 regulates expression of vascular endothelial growth factor and osteopontin after tooth extraction

open access: yesJournal of Periodontology, EarlyView.
Abstract Background The present study aimed to investigate the expression of stromal cell‐derived factor‐1 (SDF‐1) after tooth extraction in rats and its regulatory effect on the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF).
Jingjing Kong   +5 more
wiley   +1 more source

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen   +4 more
wiley   +1 more source

Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK‐3β Axis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sacubitril/valsartan (Sac/Val) has emerged as an effective compound with myocardium‐protective functions in experimental and clinical trials for heart failure. This study investigated the function of Sac/Val in hypertensive heart disease (HHD) and explored the underlying mechanism.
Yan‐Jun Yang, Jiu‐Sheng Li
wiley   +1 more source

Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia

open access: yesMovement Disorders, EarlyView.
Abstract Background Tardive dyskinesia (TD) and drug‐induced parkinsonism (DIP) arise from prolonged dopamine antagonist use. Although D2 receptor hypersensitivity in the indirect pathway is a proposed mechanism, the role of the direct pathway remains unclear.
Hiroki Hikichi   +6 more
wiley   +1 more source

Rapid eye movement sleep deprivation induced gene regulation for modulation of noradrenaline level in brain regions of rats: Implications with chronic sleep‐loss associated pathophysiological conditions

open access: yesNeuroprotection, EarlyView.
Proposed mechanism for transcriptional regulation of tyrosine hydroxylase (TH), dopamine β hydroxylase (DBH) and monoamine oxidase‐A (MAO‐A) genes during rapid eye movement sleep (REMS) or its loss. Increased histone acetylation and decreased histone methylation of TH and DBH gene favor chromatin opening, increase in gene expressions, increased enzyme ...
Rachna Mehta   +2 more
wiley   +1 more source

Fructose consumption and metabolic hypertension in rats: a systematic review and meta-analysis. [PDF]

open access: yesPeerJ
Vs A   +11 more
europepmc   +1 more source

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