Results 181 to 190 of about 391,386 (289)

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

open access: yesAddiction, EarlyView.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu   +8 more
wiley   +1 more source

Hormonal Treatment During Ex Vivo Lung Perfusion Ameliorates Brain Death Induced Inflammation

open access: yesArtificial Organs, EarlyView.
Treatment of lungs during ex vivo perfusion with 17β‐estradiol and methylprednisolone improved graft quality. In females, treated and non‐treated groups presented reduced leukocyte infiltration and only the treatment improved perfusion flow. In males, treatment improved lung function by increasing compliance, paO2, and perfusion flow.
Marina Vidal‐dos‐Santos   +9 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

open access: yesBritish Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli   +7 more
wiley   +1 more source

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam   +12 more
wiley   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado   +6 more
wiley   +1 more source

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