Results 161 to 170 of about 118,351 (244)

Somatostatin Mitigates Gastric Mucosal Damage Induced by LPS in a Male Wistar Rat Model of Sepsis. [PDF]

Biomolecules
Paredes SD, Hernández-Cortés J, Falahat F, Rancan L, Arias-Díaz J, Vara E.   +5 more
europepmc   +1 more source

Growth differentiation factor 15 mitigates lipotoxic steatosis by preserving mitochondrial morphodynamics and augmenting fatty acid oxidation in hepatocytes and liver organoids

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Growth differentiation factor 15 (GDF15) has emerged as a promising metabolic regulator with hepatoprotective properties in metabolic dysfunction‐associated steatotic liver disease (MASLD), yet its underlying mechanisms remain elusive.
Jia Li, Qi Zhou, Mengmeng Xia, Yakun Li, Junyu Wang, Manon Buist‐Homan, Vincent E. de Meijer, Hans Blokzijl, Klaas Nico Faber, Han Moshage   +9 more
wiley   +1 more source

An electrophysiological early marker of age-related hearing loss in the Wistar rat model. [PDF]

Heliyon
Alvarado JC, Fuentes-Santamaría V, Benítez-Maicán Z, Díaz García CM, Gabaldón Ull MC, Juiz JM.   +5 more
europepmc   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

The FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf, Cassandra Duda, Tihomir Kostov, Patrick Diel, Käthe Bersiner, Wilhelm Bloch, Sebastian Gehlert, Daniel Jacko   +7 more
wiley   +1 more source

Preclinic evaluation of the safety of potential anticovid-19 phytomedicine: SAYE PLUS impacts on Wistar rat biochemical and histopathological parameters in sub-chronic toxicity study. [PDF]

BMC Pharmacol Toxicol
Ouédraogo J, Ilboudo S, Ouédraogo GG, Somda GD, Bonogo B, Dakuyo V, Ouédraogo S, Boly R, Nitiéma M, Magnini DR, Semdé R, Ouédraogo S.   +11 more
europepmc   +1 more source

Natural‐based antioxidants in cosmeceuticals: Extraction, bioavailability and skin ageing applications

International Journal of Cosmetic Science, EarlyView.
Natural antioxidants from plants, fruits, seeds and fungi combat ageing by neutralizing free radicals, boosting collagen and protecting against UV damage. Enhanced by green extraction and smart delivery systems, they offer powerful anti‐inflammatory and antimicrobial benefits.
Hossein Omidian, Arnavaz Akhzarmehr, Charise Dallazem Bertol   +2 more
wiley   +1 more source

Evaluation of PTSD-Induced Alterations in Bone Biomechanics and the Protective Potential of CE-123 in a Wistar Rat Model. [PDF]

J Clin Med
Osiak-Wicha C, Kras K, Tomaszewska E, Muszyński S, Grochecki P, Kotlińska JH, Słowik T, Świetlicki M, Arciszewski K, Lubec G, Arciszewski MB.   +10 more
europepmc   +1 more source

Multiple Periapical Lesions Influence the Expression of TLR4/NF‐κB Pathway Components and the Development of Hepatic Injuries in Healthy and Chronic Alcohol‐Consuming Rats

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate the impact of multiple apical periodontitis (AP) on the expression of TLR4/NF‐κB pathway components, proinflammatory cytokine levels, and development of hepatic injuries in rats with and without chronic alcohol consumption. Methodology Thirty‐two rats were assigned to four groups (n = 8): Control, AP, Alcohol, and Alcohol+AP ...
Karem Paula Pinto, Isabelle da Cunha Degani, Jenif Braga de Souza, Renata Heisler Neves, Luciana Brandão‐Bezerra, Luciana Moura Sassone, Emmanuel João Nogueira Leal da Silva   +6 more
wiley   +1 more source

Integrative Computational and Experimental Approaches Reveal the Protective Role of Moderate Caffeine Intake Against Apical Periodontitis Induced Bone Loss

International Endodontic Journal, EarlyView.
ABSTRACT Aim To investigate whether moderate systemic caffeine intake modulates the progression of apical periodontitis (AP) and associated alveolar bone loss, combining in vivo rat experiments with in silico molecular docking to explore potential mechanisms. Methodology Male Wistar rats were randomly assigned to four groups (n = 8 per group): control,
Matheus Ferreira Lima Rodrigues, Deborah Ribeiro Frazão, Deiweson Souza‐Monteiro, Vinicius Ruan Neves dos Santos, Felipe Oliveira Nunes, João Daniel Mendonça de Moura, Thamires Campos Gomes, Jorddy Neves Cruz, Cristiane do Socorro Ferraz Maia, Rodrigo A. Cunha, Fabrício Mezzomo Collares, Rogerio de Castilho Jacinto, Rafael Rodrigues Lima   +12 more
wiley   +1 more source

Nephroprotective effect of pioglitazone in a Wistar rat model of adenine‑induced chronic kidney disease. [PDF]

Exp Ther Med
Pérez-Villalobos MC, Barba-González A, García-Carrillo N, Muñoz-Ortega MH, Sánchez-Alemán E, Ávila-Blanco ME, Morones-Gamboa JC, Ventura-Juárez J, Martínez-Hernández SL.   +8 more
europepmc   +1 more source