Results 271 to 280 of about 237,978 (340)

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Antihypertrophic effects of the seed ethanolic extract of Aframomum pruinosum Gagnep. (Zingiberaceae) against isoproterenol-induced cardiac hypertrophy in male Wistar rat. [PDF]

Toxicol Rep
Goumtsa AF, Nguelefack-Mbuyo EP, Nokam F, Koho CW, Dial CMM, Nguelefack TB.   +5 more
europepmc   +1 more source

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Evaluation of the Effects of Opium on the Expression of SOX2 and OCT4 in Wistar Rat Bladder. [PDF]

Bladder Cancer
Menbari Oskouie I, Zareian Baghdadabad L, Mashhadi R, Zahmatkesh P, Mirzaei A, Khajavi A, Noori M, Mesbah G, Aghamir SMK.   +8 more
europepmc   +1 more source

Effects of cell therapy on seizures in animal models of epilepsy: Systematic review and meta‐analysis

Epilepsia, EarlyView.
Abstract This study was undertaken to systematically evaluate the efficacy of cell therapy in reducing seizures in animal models of chronic epilepsy. Three databases, Ovid MEDLINE, Ovid Embase, and Web of Science, were searched using predetermined eligibility criteria.
Afaf S. Altalhi, Muhammad S. Javaid, Nigel C. Jones, Kim L. Powell, Patrick Kwan, Terence J. O'Brien, Ana Antonic‐Baker   +6 more
wiley   +1 more source

Possible relationship between pre-pregnancy maternal body mass index and offspring hippocampus: An experimental study in albino Wistar rat. [PDF]

Open Vet J
Greash ZA, Elmajdoub LO, Fayad E, Almaaty AHA.   +3 more
europepmc   +1 more source

Dose response and time course studies on superoxide dismutase as a urinary biomarker of carbon tetrachloride‐induced hepatic injury in the Hanover Wistar rat

, 2009
Rosemary Smyth, Michael R. Munday, Malcolm J. York, Christopher J. Clarke, Theo O. Dare, John A. Turton   +5 more
openalex   +2 more sources

D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2

The FEBS Journal, EarlyView.
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua, Yee Song Chong, Sreedharan Sajikumar   +2 more
wiley   +1 more source

Protective impact of Betanin against noise and scrotal hyperthermia on testicular toxicity in Wistar rat: Role of apoptosis, oxidative stress and inflammation. [PDF]

Heliyon
Bijani S, Naserzadeh P, Hosseini MJ.
europepmc   +1 more source