Results 171 to 180 of about 328,483 (267)

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan   +4 more
wiley   +1 more source

Impact of Goji Berry Juice on Redox Status in Wistar Rats: A Subchronic Toxicity Assessment. [PDF]

open access: yesInt J Mol Sci
Rodrigues CF   +6 more
europepmc   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

open access: yesEuropean Journal of Oral Sciences, EarlyView.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves   +7 more
wiley   +1 more source

Resistance‐exercise‐induced stress intervenes in TGF‐β signaling by cooperatively downregulating nuclear αB‐crystallin and SMAD4 in human skeletal muscle fibers

open access: yesThe FEBS Journal, EarlyView.
Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf   +7 more
wiley   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

open access: yesThe FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz   +13 more
wiley   +1 more source

Lifestyle triggers of migraine: Sleep restriction and caffeine lower the threshold for migraine‐like responses in rats in a sex‐specific manner

open access: yesHeadache: The Journal of Head and Face Pain, EarlyView.
Sleep restriction (SR) and caffeine intake act as environmental modulators of migraine susceptibility. Their effects are sex‐dependent: Females show heightened sensitivity under both SR and caffeine conditions. Males require the combination of SR and caffeine to exhibit susceptibility.
Gabriel Camargo de Oliveira   +7 more
wiley   +1 more source

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