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Genotoxicity of nimesulide in Wistar rats
Drug and Chemical Toxicology, 2013It is mandatory for all new drugs to be tested for their potential genotoxicity in addition to general toxicity testing. Some old drugs have not been tested adequately for their genotoxic effects because these were in use before the local regulations were enforced. According to the material safety database, the toxicological effect of nimesulide is not
Debojyoti, Borkotoky +3 more
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Endocardial Schwannomas in the Wistar Rat
Journal of Veterinary Medicine Series A, 2005SummaryEndocardial neoplasms were observed in 13 Wistar rats, 15–30 months old, from a 30‐month inhalation study. Eight of the rats were dissected at 30 months and the other five between 15 and 29 months. Histologically, the lesions in the heart were diagnosed as endocardial schwannomas.
A, Teredesai, T, Wöhrmann
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METABOLISM OF MYOSMINE IN WISTAR RATS
Drug Metabolism and Disposition, 2005The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine. Due to its widespread occurrence, investigations on the metabolism and activation of myosmine are needed for risk ...
Wolfgang, Zwickenpflug +2 more
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Hepatotoxicity of graphene oxide in Wistar rats
Environmental Science and Pollution Research, 2020Graphene oxide (GO) has a multitude of applications in areas of nanomedicine, electronics, textile, water purification, and catalysis among others. GO is relatively easier to manufacture and customize as compared with other carbon-based nanomaterials.
Naresh K. Nirmal +2 more
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A supernumerary forelimb in a Wistar rat
Laboratory Animals, 1987A fifth limb, quite independent of the others, was found in a pup born in our colony of Wistar rats. The malformation is described.
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Acetaminophen nephrotoxicity in male Wistar rats
Archives of Toxicology, 1992Acute acetaminophen (APAP) nephrotoxicity was studied in male Wistar rats 1 h after different APAP single doses (200, 500 and 1000 mg/kg body wt, i.p.). Significant impairments in glomerular filtration rate (GFR) and clearance of p-aminohippuric acid (ClPAH) were observed in a dose-dependent way, although tubular parameters measured, water and ...
L, Trumper, G, Girardi, M M, Elías
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MODELING AND SYNTHESIS OF THE WISTAR RAT ELECTROCARDIOGRAM
Journal of Biological Systems, 2023In this work, we present a synthesizer of electrocardiographic signals of the experimental model of the Wistar rat. Firstly, we modeled the P, R, and S waves using Gaussian functions, while for the T-wave, we used a Gumbel function. We validated the proposed model using a Wistar rat electrocardiogram database, which contains 41 animals with 62,907 ...
Caracciolo, Santiago Federico +2 more
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Induced palatal candidosis in the Wistar rat
Archives of Oral Biology, 1981Palatal candidosis was induced by inoculating Candida albicans 3091 (serotype A) under an acrylic appliance. After 1 week, the palatal epithelium showed acute inflammatory cell infiltration and surface colonization by blastospores. Two weeks after inoculation, the inflammation had increased, micro-abscesses were observed and fungal hyphae penetrated ...
B S, Shakir, M V, Martin, C J, Smith
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Polymorphism in Diazepam Metabolism in Wistar Rats
Journal of Pharmaceutical Sciences, 2004We observed variations in the metabolism of diazepam in Wistar rats. We studied these variations carefully, and found that the variations are dimorphic and about 17% of male rats of Wistar strain we examined showed two times higher diazepam metabolic activities in their liver microsomes than the rest of animals at the substrate concentrations less than
Konomu, Saito +5 more
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Tumor-Induced Anorexia in the Wistar Rat
Science, 1981The transplantable Leydig cell tumor of Wistar rats, LTW(m), caused decreased food consumption and weight loss in the host within 2 weeks of implantation. The tumor was small, did not metastasize, and did not affect several parameters of biochemical function.
J P, Mordes, A A, Rossini
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