Results 31 to 40 of about 168,253 (297)

Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth

Advanced Functional Materials, EarlyView.
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung, Chu‐Chun Liang, Min‐Wei Huang, Tianle Chen, Joshua M. Little, Snehi Shrestha, Yi‐Chen Ethan Li, I‐Chi Lee, Po‐Yen Chen   +8 more
wiley   +1 more source

POTENTIAL OF JAMBLANG (Syzygium cumini L.) LEAF EXTRACT ON BODY WEIGHT OF WISTAR RATS METABOLIC SYNDROME MODEL

Jurnal Riset Kesehatan, 2021
Jamblang (Syzygium cumini L.) leaves contain several phytochemical compounds. These phytochemicals are thought to have roles as antihyperglycemic, antihyperlipidemic, and antioxidant agents.
Ida Nurwati, Risya Cilmiaty AR, Danus Hermawan, Betty Saptiwi, Dyah Ratna Budiani, Jarot Subandono, Martini Martini, Muthmainah Muthmainah, Sarsono Sarsono, Selfi Handayani   +9 more
doaj   +1 more source

Reservoir‐Type Subcutaneous Implantable Devices Containing Porous Rate Controlling Membranes for Sustained Delivery of Risperidone

Advanced Healthcare Materials, EarlyView.
This study presents a novel implantable drug delivery systemwith a biodegradable poly(caprolactone) membrane and compressed drug core forsustained release. These implantable devices deliver risperidone in vitro for 170 days and in vivo for 49 days in rats, showing promise for chronic conditions like schizophrenia.
Linlin Li, Andi Dian Permana, Juan Domínguez‐Robles, Muh Nur Amir, Habibie Habibie, Qonita Kurnia Anjani, Li Zhao, Natalia Moreno‐Castellanos, Ryan F Donnelly, Eneko Larrañeta   +9 more
wiley   +1 more source

Permeation Enhancer‐based Ionogel Shows Remarkable Potential for Oral Insulin Delivery

Advanced Healthcare Materials, EarlyView.
This study proposes a novel formulation of decanoate in an ionic liquid inspired drug delivery system. The formulation demonstrates ideal physicochemical and material properties for oral peptide delivery. Findings indicate that choline decanoate (1:2 molar ratio) forms a viscoelastic gel that enables high oral bioavailability of insulin in rats ...
Konstantinos Raptis, Joanne Heade, Cristiana Cunha, Marco van de Weert, Lasse Saaby, Stine Rønholt, Hanne Mørck Nielsen   +6 more
wiley   +1 more source

Clinico-pathology, diagnosis and management of Cysticercus fasciolaris and Hymenolepis diminuta co-infection in wistar rats [PDF]

Veterinary World, 2015
Aim: The present study was undertaken to study the pathology and control of sudden unexplained mortality in wistar rats. Materials and Methods: This study was conducted in a colony of 25 male wistar rats where there was mortality of nine rats.
Y. Damodar Singh , Rahul Singh Arya
doaj   +1 more source

Automated Transcranial Photobiomodulation in Healthy Rats: Effects on Working Memory and Brain Markers

Advanced Therapeutics, EarlyView.
Transcranial photobiomodulation (PBM) enhances spatial working memory in healthy rats under both continuous and alternating stimulation protocols. At the neural level, PBM modulates cytochrome c oxidase activity, increases prefrontal and hippocampal synaptic markers, and induces region‐specific c‐Fos expression. These effects suggest improved cognitive
Candela Zorzo, Lucía Rodríguez‐Fernández, Emily Gabriela Castillo‐Escalona, Juan A. Martínez, Laura Mañas, Natalia Arias, Jorge L. Arias   +6 more
wiley   +1 more source

A rat model of early stage osteonecrosis induced by glucocorticoids

Journal of Orthopaedic Surgery and Research, 2011
Background Glucocorticoid (GC)-induced osteonecrosis (ON) is an important complication of medical therapy. The exact pathomechanisms of ON has not been clearly elucidated.
Kerachian Mohammad, Harvey Edward J, Cournoyer Denis, Chow Terry Y, Nahal Ayoub, Séguin Chantal   +5 more
doaj   +1 more source

Dilated cardiomyopathy in a wistar rat.

Journal of Toxicologic Pathology, 1995
A 57-week-old male Wistar rat died one week before the end of a toxicity study. Necropsy revealed subcutaneous edema, hydrothorax, dilatation of all cardiac chambers, and congestion in several organs. Light and electron microscopic examinations revealed myocardial hypertrophy, degeneration, fibrosis, and disruption of myofibrils and variable sized ...
Yoshimasa Okazaki, Osamu Katsuta, Junko Matsumoto, Minoru Tsuchitani   +3 more
openaire   +3 more sources

Non‐Invasive Diagnosis of Chronic Myocardial Infarction via Composite In‐Silico‐Human Data Learning

Advanced Science, EarlyView.
This study presents a non‐invasive machine learning model to identify infarct regions in the left ventricle using cardiac strain data. By combining rodent‐based simulated data with limited human data, the model achieves high accuracy in predicting infarct size and location without the need for gadolinium contrast agents, offering a promising ...
Rana Raza Mehdi, Nikhil Kadivar, Tanmay Mukherjee, Emilio A. Mendiola, Akila Bersali, Dipan J. Shah, George Karniadakis, Reza Avazmohammadi   +7 more
wiley   +1 more source

Histologic Effects of Carbonated Drinks on Rat Kidney

Journal of Rawalpindi Medical College, 2015
Background: To study the histologic effects of carbonated drinks on rat kidneys Methods: In this experimental animal study histological changes on rat kidney caused by chronic consumption of carbonated drinks were observed.
Ayesha Fahim
doaj