Results 201 to 210 of about 566,442 (300)

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

open access: yesAdvanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin   +13 more
wiley   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

open access: yesAdvanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh   +11 more
wiley   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

open access: yesAdvanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang   +12 more
wiley   +1 more source

Axial F–Bi–Ov Electron Pump Drives Continuous Reconfiguration of Bi Sites for Efficient Photocatalytic N2 Reduction

open access: yesAdvanced Science, EarlyView.
Axial Fluorine and Light‐Induced Oxygen Vacancies Synergize as an Electron Pump to Lower N2 Activation Energy and Enable Sustained NH3 Synthesis on FBWO. ABSTRACT The electronic structure precision of single‐atom catalysts (SACs) represents a decisive factor limiting advancements in photocatalytic nitrogen reduction (NRR) efficiency.
Xiao Ge   +6 more
wiley   +1 more source

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