Results 211 to 220 of about 2,454,762 (255)

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis. [PDF]

J Med Virol
Caillault A, Xhaard A, Mercier-Delarue S, Feghoul L, Robert J, Schnepf N, Michonneau D, Robin M, Sicre de Fontbrune F, Kaphan E, Ruggiu-Goiran M, de Lima Prata PH, Chevillon F, Jestin M, Dhedin N, Socie G, Peffault de Latour R, Salmona M, LeGoff J.   +18 more
europepmc   +1 more source

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

Transient restructuring of the active oral resistome during probiotic <i>Streptococcus salivarius</i> K12 colonization in a 3D polymicrobial biofilm model. [PDF]

J Oral Microbiol
Udawatte NS, Liu C, Staples R, Han P, Kumar PS, Arumugam TV, Ivanovski S, Seneviratne CJ.   +7 more
europepmc   +1 more source

TiO6 as a Compensatory Structural Unit in Co‐Free, High‐Ni Layered Oxide for Durable Lithium‐Ion Batteries

Advanced Science, EarlyView.
Ti substitution stabilizes Co‐free high‐Ni layered oxides through both structural and electronic effects. TiO6 octahedra act as compensatory structural units that help interrupt cooperative Jahn–Teller distortion and suppress detrimental phase transitions, while the electron‐withdrawing inductive effect of Ti stabilizes the oxygen lattice. As a result,
Bixian Ying, Zhenjie Teng, Jun Wang, Honghong Tian, Charlotte von Petersdorff‐Campen, Rommel T. Tolla, Iuliia Mikulska, Linus Voigt, Sascha Nowak, Verena Naber, Alexander Schökel, Yuanming Liu, Michael Merz, Peter Nagel, Stefan Schuppler, Katja Frenzel, Adrian Jonas, Lena Mathies, Martin Winter, Karin Kleiner   +19 more
wiley   +1 more source

Ecological Dynamics of <i>Staphylococcus aureus</i> in Raw Ewe Milk Following Different Mastitis Treatment Protocols. [PDF]

Antibiotics (Basel)
Fotou K, Rozos G, Nikolaou K, Gerokomou V, Dadamogia A, Vouraki S, Demertzis P, Akrida-Demertzi K, Vasileiou NGC, Skoufos I, Tzora A, Voidarou CC.   +11 more
europepmc   +1 more source

Interfacial Electric Field Engineering of High‐Entropy Heterostructures Triggering Self‐Limiting Reconstruction for Industrial‐Scale Electrocatalysis

Advanced Science, EarlyView.
An interfacial electric field engineering strategy is proposed to trigger the self‐limiting surface reconstruction of high‐entropy heterostructures. Driven by this built‐in field, the controlled sacrificial leaching of W evolves a robust active layer, enabling exceptional oxygen evolution performance and ultrastability at ampere‐level current densities
Liang Yan, Yueqi Zhang, Bing Zhang, Jingyi Ye, Hao Li   +4 more
wiley   +1 more source

Investigating the effect of eye movement desensitization and reprocessing on internalized stigma in patients with major depressive disorder: a randomized controlled trial. [PDF]

BMC Psychiatry
Behnammoghadam M, Shojaossadati N, Pendar R, Malekzadeh M, Roustaei N.   +4 more
europepmc   +1 more source