Results 151 to 160 of about 291,899 (358)

Tislelizumab: Structural Innovations and Expanding Clinical Horizons in Next‐Generation PD‐1 Immunotherapy

Chronic Diseases and Translational Medicine, EarlyView.
The interaction of tislelizumab with PD‐1/PD‐L1 in the tumor microenvironment. Tislelizumab targets PD‐1 on T cells, blocking its interaction with PD‐L1 on tumor cells. This action is facilitated by a modified F(ab) region that limits Fc‐γ receptor binding, thereby enhancing the antitumor immune response. ABSTRACT Tislelizumab is a next‐generation PD‐1
Thy T. Nguyen, Bohan Zhang, Luke Zhong, Xiuyi Liang, Letao Bo   +4 more
wiley   +1 more source

Biochemical alterations during medication withdrawal in Parkinson's disease with and without neuroleptic malignant-like syndrome [PDF]

, 2001
Masayuki Ueda
openalex   +1 more source

Supporting Black Women in Counselor Education Through Holistic Writing Retreats

Counselor Education and Supervision, EarlyView.
ABSTRACT This study investigates the role of the Melanin Scholars Retreat, a writing and wellness retreat that centers the voices of Black women faculty and doctoral students in counselor education, in supporting their professional and personal well‐being.
Aiesha T. Lee, Natoya Haskins, Galaxina G. Wright, Brittany Williams, Briana Gaines, Janelle Jones, Atiya R. Smith   +6 more
wiley   +1 more source

Prevention of Cannabinoid Withdrawal Syndrome by Lithium: Involvement of Oxytocinergic Neuronal Activation [PDF]

, 2001
Shusen Cui, Rudy Bowen, Guibao Gu, Darren K. Hannesson, Peter H. Yu, Xia Zhang   +5 more
openalex   +1 more source

The Role of Five‐Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview

ChemMedChem, EarlyView.
Several derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Claudia Finamore, Carmen Festa, Rosa Barbato, Stefano Fiorucci, Angela Zampella, Simona De Marino   +5 more
wiley   +1 more source

Disparity between General Symptom Relief and Remission Criteria in the Positive and Negative Syndrome Scale (PANSS): A Post-treatment Bifactor Item Response Theory Model. [PDF]

, 2017
Objective: Total scale scores derived by summing ratings from the 30-item PANSS are commonly used in clinical trial research to measure overall symptom severity, and percentage reductions in the total scores are sometimes used to document the efficacy of
Anderson, Ariana E, Bilder, Robert M, Han, Carol, Mansolf, Maxwell, Marder, Stephen R, Reise, Steven P   +5 more
core  

Comparison of two nicotine dependence measures for use with Korean American Women: The FTND and AUTOS

, 2017
This study compares psychometric properties of the Fagerström Test for Nicotine Dependence (FTND) and Autonomy over Tobacco Scale (AUTOS), which are measures of nicotine dependence.
Kim, Sun S, PhD, APRN-BC
core   +1 more source

Preventive and therapeutic effects of taurine in ethanol withdrawal syndrome in mice

, 1977
Masanori Akiyama, Kazuhito Kawata, Shoji Saito   +2 more
openalex   +1 more source

Venlafaxine withdrawal syndrome not prevented by maprotiline, but resolved by sertraline [PDF]

, 2001
Christian Luckhaus, Christian C. Jacob
openalex   +1 more source

Microtracer‐Based Assessment of the Mass Balance, Pharmacokinetics, and Excretion of [14C]Berzosertib, an Intravenous ATR Inhibitor, in Patients With Advanced Solid Tumors: A Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula, Holger Scheible, Florian Huber, Annick Seithel‐Keuth, Hanno Schieferstein, Deepthi S. Vagge, Nadra Mammasse, Eva Jaks, Jordi Ferrer, Camilo Moulin, Jennifer Dong, Karthik Venkatakrishnan, Zsuzsanna Papai   +12 more
wiley   +1 more source