Results 31 to 40 of about 53,534 (236)

COMPARING TWO TRANSECT METHODS FOR THE DETECTION OF RED-BACKED SALAMANDERS [PDF]

, 2016
Typical monitoring methods for terrestrial salamanders are subject to extensive variation, driven by the environmental conditions in effect during sampling.
Killian, Michael D., McGhee, Jay D.
core   +2 more sources

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Potential of a new warm asphalt mix by using soft asphalt and rock asphalt compound

International Journal of Transportation Science and Technology
Warm mix asphalt (WMA) has gained significant attention in the asphalt industry, traditionally dominated by Hot mix asphalt (HMA), due to its advantages in reducing energy consumption and lowering carbon emissions.
Yanna Sun, Jiawei Zhang, Lihan Li, Tong Lu   +3 more
doaj   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

ANALISIS TEKNIKAL PERGERAKAN HARGA SAHAM DENGAN MENGGUNAKAN INDIKATOR STOCHASTIC OSCILLATOR DAN WEIGHTED MOVING AVERAGE

Keunis, 2021
Investments in the stock market are closely related to the price movement risk. Investors used technical analysis to minimize the risk caused by changes in stock prices. Hence, investors get the right decision to buy or sell the stocks.
Nur Alviyanil 'Izzah, Dina Yeni Martia, Maria Imaculata, Moh Iqbal Hidayatullah, Andhika Bagus Pradana, Diyah Ayu Setiyani, Enes Sapuri   +6 more
doaj   +1 more source

Youngsters and WMAs (WeChat Moments Advertisement): Do We Need the English Language in WMAs? [PDF]

Sage Open, 2020
Social media marketing is considered an integral part of the today’s marketing plans alongside the conventional tools. Social media’s practical application has changed the way of communication between organizations and consumers. In particular, the dynamics of interactions have been diversified in the Chinese technological cross-cultural environment ...
Muhammad Zahid Nawaz, Meng Tao, Hassan Ahmad, Md Jamirul Haque, Shahid Nawaz, Muhammad Nauman Shafique   +5 more
openaire   +2 more sources

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Sustainable production of WMA with pine gum wax modification

Journal of Innovative Transportation
Warm mix asphalt (WMA) (S®-WMA) produced with Sasobit® (S®), a widely used organic admixture, shows a significant increase in softening point value and a decrease in stripping resistance.
İslam Gokalp, Ramazan Yani
doaj   +1 more source

The impact of the first COVID-19 lockdown on weight management practices in UK adults: A self-regulation perspective

Health Psychology Open, 2023
This study aimed to identify the impact of the first UK COVID-19 lockdown on individuals’ weight management attempts (WMA). A self-regulation theoretical framework was used to identify predictors of continuing with a WMA, and weight change during the ...
Denisa Genes, Fuschia M Sirois, Nicola J Buckland   +2 more
doaj   +1 more source