Results 291 to 300 of about 459,861 (330)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Inhibition of Wnt signaling in primary human hepatocytes promotes Plasmodium falciparum liver stage development. [PDF]

PLoS Pathog
Kanyal A, van Gemert GJ, Wu H, van der Starre A, de Wilt JHW, Bousema T, Sauerwein RW, Bártfai R, Yang ASP.   +8 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

(Non)canonical Wnt signaling, cytoarchitecture and stemness: new insights from primary nonmetastatic, primary metastatic, regional and distant metastatic models of adrenocortical carcinoma. [PDF]

Exp Mol Med
Shapiro I, Debaix H, Kräuchi C, Abate A, Bornstein SR, Nölting S, Gunz S, Berruti A, Sigala S, Beuschlein F, Luca E, Hantel C.   +11 more
europepmc   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Assessment of miRNA 106a-5p and 375-3p Expression in the Context of the Wnt/β-Catenin Pathway-Comparison of Prostate Adenocarcinoma and Benign Prostatic Hyperplasia Tissues. [PDF]

Int J Mol Sci
Smereczańska M, Domian N, Młynarczyk G, Kasacka I.   +3 more
europepmc   +1 more source

The Impact of Air Pollution and Obesity on Cognitive Decline and Risk of Alzheimer's Disease. [PDF]

Int J Mol Sci
Keller ZA, Eggers KM, Nixon JP, Butterick TA.   +3 more
europepmc   +1 more source

CLEC4G Reverses Lenvatinib Resistance in Hepatocellular Carcinoma by Suppressing PD-1 Expression via the Wnt/<i>β</i>-Catenin Pathway. [PDF]

Int J Genomics
Xiao K, Yan J, He G, He B, Wang Q.
europepmc   +1 more source

COUP-TFI modulates the expression of Wnt-downstream genes in the embryonic hippocampal neuroepithelium.

Ching-San Tseng (6252566), Zi-hui Zhuang (22120612), Hsiang-Wei Hsing (22120615), Chia-Ming Lee (12987725), Tsan-Ting Hsu (8639409), Yu-Kuan Pan (22120618), Yi-Ping Hsueh (5601602), Bi-Chang Chen (2656468), Shen-Ju Chou (6252569)   +8 more
openalex   +1 more source