Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone. [PDF]
PLoS ONE, 2015 Genome Wide Association Studies suggest that Wnt16 is an important contributor to the mechanisms controlling bone mineral density, cortical thickness, bone strength and ultimately fracture risk.
Henry Todd +6 more
doaj +6 more sources
Induction of WNT16 via Peptide-mRNA Nanoparticle-Based Delivery Maintains Cartilage Homeostasis [PDF]
Pharmaceutics, 2020 Osteoarthritis (OA) is a progressive joint disease that causes significant disability and pain and for which there are limited treatment options. We posit that delivery of anabolic factors that protect and maintain cartilage homeostasis will halt or ...
Huimin Yan +6 more
doaj +3 more sources
WNT16 from decidual stromal cells orchestrates M2 macrophage polarization via β-catenin signaling and chromatin remodeling at the maternal-fetal interface [PDF]
Frontiers in ImmunologyBackgroundPregnancy maintenance requires precise immunoregulation at the maternal-fetal interface, where M2-polarized decidual macrophages (dMφ) support immune tolerance.
Lingyu Chang +9 more
doaj +2 more sources
Wnt16 Elicits a Protective Effect Against Fractures and Supports Bone Repair in Zebrafish [PDF]
JBMR Plus, 2021 Bone homeostasis is a dynamic, multicellular process that is required throughout life to maintain bone integrity, prevent fracture, and respond to skeletal damage.
Lucy M McGowan +5 more
doaj +3 more sources
Wnt16: a new potential therapeutic target for osteoporotic non-vertebral fracture treatment [PDF]
Frontiers in AgingOsteoporotic non-vertebral fractures are a major clinical burden, with cortical bone impairment being a key pathogenic factor often overlooked in traditional treatments.
Chen Tianpeng +7 more
doaj +2 more sources
Genetic variation in WNT16 and its association with bone mineral density, fractures and osteoporosis in children with bone fragility [PDF]
Bone Reports, 2022 Several genome-wide association studies (GWAS), GWAS meta-analyses, and mouse studies have demonstrated that wingless-related integration site 16 (WNT16) gene is associated with bone mineral density (BMD), cortical bone thickness, bone strength and ...
R.E. Mäkitie +3 more
doaj +3 more sources
Non-Canonical Wnt16 and microRNA-145 Mediate the Response of Human Bone Marrow Stromal Cells to Additively Manufactured Porous 3-Dimensional Biomimetic Titanium–Aluminum–Vanadium Constructs [PDF]
CellsMetal 3D printing is increasingly being used to manufacture titanium–aluminum–vanadium (Ti6Al4V) implants. In vitro studies using 2D substrates demonstrate that the osteoblastic differentiation of bone marrow stromal cells (MSCs) on Ti6Al4V surfaces ...
David. J. Cohen +5 more
doaj +2 more sources
Unveiling the Regulatory Mechanism of Tibetan Pigs Adipogenesis Mediated by WNT16: From Differential Phenotypes to the Application of Multi-Omics Approaches [PDF]
AnimalsThe aim of this study is to investigate the physiological characteristics and regulatory mechanisms of porcine intramuscular fat (IMF), subcutaneous fat (take back fat (BF), for example), and visceral fat (take perienteric fat (PF), for example) to ...
Qiuyan Huang +13 more
doaj +2 more sources
Microgel Encapsulated Mesoporous Silica Nanoparticles for Releasing Wnt16 to Synergistically Treat Temporomandibular Joint Osteoarthritis [PDF]
Advanced ScienceTemporomandibular joint osteoarthritis (TMJOA) is a commonly encountered degenerative joint disease in oral and maxillofacial surgery. Recent studies have shown that the excessive unbalanced activation of Wnt/β‐catenin signaling is connected with the ...
Yan Zhu +8 more
doaj +2 more sources
Regulation of WNT16 in bone may involve upstream enhancers within CPED1 [PDF]
Scientific ReportsWNT16 stands up as an essential gene for bone homeostasis. Here, we present new evidence of the functional role of a particular region within WNT16.
N. Martínez-Gil +10 more
doaj +2 more sources